Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion - Wikidata - wikimedia - TriplyDB

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

http://www.wikidata.org/entity/Q30434675

about

CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy DNA repair targeted therapy: The past or future of cancer treatment?Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Targeting the Checkpoint to Kill Cancer Cells Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer DNA damage response genes and the development of cancer metastasis Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin The miR-99 family regulates the DNA damage response through its target SNF2H Synthesis of water-soluble camptothecin-polyoxetane conjugates via click chemistry DNA damage response during mouse oocyte maturation.Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity.ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks.CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer.Controlling the Mdm2-Mdmx-p53 Circuit.Targeting DNA repair pathways for cancer treatment: what's new?The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling.Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents.Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis New insights into checkpoint kinase 1 in the DNA damage response signaling network.Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.ATM signalling and cancer.The ATM protein: the importance of being active.Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation Defining a genotoxic profile with mouse embryonic stem cells Tug of war between survival and death: exploring ATM function in cancer.Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators Gene expression changes in residual advanced cervical cancer after radiotherapy: indicators of poor prognosis and radioresistance?Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses The COP9 signalosome is vital for timely repair of DNA double-strand breaks.Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells

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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

http://www.wikidata.org/entity/Q30434675

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Improved ATM kinase inhibitor ...... nhibits migration and invasion

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Improved ATM kinase inhibitor ...... nhibits migration and invasion

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type

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Improved ATM kinase inhibitor ...... nhibits migration and invasion

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Improved ATM kinase inhibitor ...... nhibits migration and invasion

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Improved ATM kinase inhibitor ...... nhibits migration and invasion

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Improved ATM kinase inhibitor ...... nhibits migration and invasion

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Molecular Cancer Therapeutics

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Improved ATM kinase inhibitor ...... nhibits migration and invasion

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Elizabeth Rosenberg

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Isa Hussaini

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Keith A Menear

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Kristoffer Valerie

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Laurent Rigoreau

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Lawrence F Povirk

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Marc Hummersone

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Mark Frigerio

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Mark J O'Connor

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Sarah E Golding

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P2860

Regulation and mechanisms of mammalian double-strand break repair

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A

Substrate specificities and identification of putative substrates of ATM kinase family members

ATM and ATR: networking cellular responses to DNA damage

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

ATM and related protein kinases: safeguarding genome integrity

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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2894-2902

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10.1158/1535-7163.MCT-09-0519

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10

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8

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Nicholas Valerie

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2009-10-06T00:00:00Z

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26875954

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19808981

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2761990

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