Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
about
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapseRab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cellsExophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domainDOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytesUpdate on the regulation of mammalian melanocyte function and skin pigmentationPhysiological factors that regulate skin pigmentationIdentification of EPI64 as a GTPase-activating protein specific for Rab27AMicrophthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transportVarp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytesThe recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome traffickingThe Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytesThe C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cellsSmall GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neuronsSmall GTPase Rab12 regulates constitutive degradation of transferrin receptorA promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.Essential role of RAB27A in determining constitutive human skin colorStructure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression.Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cellsBifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transportThe molecular regulation of organelle transport in mammalian retinal pigment epithelial cells.Rab27a targeting to melanosomes requires nucleotide exchange but not effector bindingSequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cellsRole of Rab27 in synaptic transmission at the squid giant synapseDysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance.Rab27a/Slp2-a complex is involved in Schwann cell myelination.Melanosomes on the move: a model to understand organelle dynamics.Rab27 effectors, pleiotropic regulators in secretory pathways.Interplay between Rab27a effectors in pancreatic β-cells.HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.Activated Cdc42-bound IQGAP1 determines the cellular endocytic siteRab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.Purification, crystallization and preliminary X-ray crystallographic analysis of Rab27a GTPase in complex with exophilin4/Slp2-a effector.The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through trapping of Rab27A effector protein Slac2-a/melanophilin in their cytosol: development of a novel melanosome-targetinG tag.Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes.Plasma membrane repairs by small GTPase Rab3a.Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth.Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
P2860
Q24312915-351237E9-2D91-44F6-87EB-4E07B0DDBBD3Q24318516-459584B1-165A-4CDD-8944-AC4FADC72DDDQ24337681-3DD00C0C-AD35-4CB4-AD4B-F315D5D6560DQ24647160-8947186E-FC2E-43D3-BE3A-D92C5B99D285Q28237643-F120894F-5EDE-42B5-A4E1-0A5E1C039289Q28245280-1B4A3FEF-8F6B-4431-B3E0-94F574B7B3F5Q28259174-3DDD65D2-5718-4FAB-AFC7-EB8E63042B24Q28269029-A35C0738-6D1E-434B-AC49-57DBE6CB268BQ28505813-1BAD7E12-232F-413F-B54B-AE66FC090E38Q28507551-D4DF1BC0-2D07-4B19-9B85-76B971301F0CQ28507877-19CEF5C8-806C-41CF-8D92-E9D724B6B782Q28565346-6B24F9CF-0117-4BDD-A048-659B432FCC56Q28584898-CAFB9521-F411-4F1A-BDF1-4DF63D180966Q28589539-417E25DB-EB8A-4C54-89A5-9E41968F6270Q28590602-821C6E2B-3C5C-4836-901A-2F55B50582B9Q28728912-0EE9A9CE-73BB-4320-B528-53858D640054Q34606390-F00E61A0-9E0A-4676-A973-14BBBDF9E176Q36161700-CFF0876C-6D35-4CD2-89B3-87C31EF27DEDQ36208239-03071597-5C61-45AD-AFC1-8635FDDA23BEQ36275469-91F5F1F0-870A-43BC-97BD-41CF75E6920EQ36416475-99BDC65B-3BB8-48E1-B12B-EA7A23EE48B1Q36431914-610DEDC7-3935-4493-9C44-6284E2D8DF57Q36896310-4C789F9F-F1DD-47A5-A8B1-1367E590D3A7Q36925227-17B5651A-99D0-4366-B28D-D4DA1CD4E9B4Q36943096-8C940441-3DBD-48DB-A090-CD1E611F7583Q36962182-82355888-5051-4B58-91E4-25AF969FB455Q37548388-0DF90FA3-BE36-4336-90EE-AD951838C1C1Q37936489-E104F602-E8F7-4CE8-BDB2-45E5F5A2FE8DQ38107224-8E83F5C3-7E21-4C24-A427-004265B8F1C9Q38432549-FBE19F16-0F3A-4D02-9893-0B3F4C6B011CQ38903098-289ABF47-BEED-49BD-A887-5B7AEC6AE2CFQ39085232-169D71A2-DF11-4276-837C-6AC468BA79C9Q39645396-79F15214-3A5C-4CAD-BD87-20EFA1ABDA73Q39688198-2AA1A973-06BE-46EF-BEEC-C17896A0EE76Q39997500-83477D0E-B3CD-4EE5-9C17-05DFDAB3DDDEQ42095252-95F3F543-EBEB-4E13-BC26-DFB854630AA9Q42106453-8013D5A7-0D59-4A31-8E83-D47AC29EFF62Q42175750-35CEC203-F5E0-4C89-9B80-7BB7C806B3E8Q42182652-94B296F5-A1DA-44EF-98E9-174C6F2ACA17Q42323966-53058D80-2155-4524-9813-E2B3D7410868
P2860
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Rab27A-binding protein Slp2-a ...... ted cell shape in melanocytes.
@en
type
label
Rab27A-binding protein Slp2-a ...... ted cell shape in melanocytes.
@en
prefLabel
Rab27A-binding protein Slp2-a ...... ted cell shape in melanocytes.
@en
P2860
P356
P1433
P1476
Rab27A-binding protein Slp2-a ...... ated cell shape in melanocytes
@en
P2093
Taruho S Kuroda
P2860
P2888
P304
P356
10.1038/NCB1197
P577
2004-11-14T00:00:00Z