The Phox2B homeobox gene is mutated in sporadic neuroblastomas. - Wikidata - wikimedia - TriplyDB

The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

http://www.wikidata.org/entity/Q40498073

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Identification of ALK as a major familial neuroblastoma predisposition gene Cell Proliferation in Neuroblastoma Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23 Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma.Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome.Targeting MYCN in neuroblastoma by BET bromodomain inhibition MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development Carbon dioxide chemoreception and hypoventilation syndromes with autonomic dysregulation.The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.The MYCN Protein in Health and Disease.Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.A 6-gene signature identifies four molecular subgroups of neuroblastoma Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth.Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis.Structural and functional differences in PHOX2B frameshift mutations underlie isolated or syndromic congenital central hypoventilation syndrome.Cell death-based treatment of neuroblastoma.Examination of PHOX2B in adult neuroendocrine neoplasms reveals relatively frequent expression in phaeochromocytomas and paragangliomas.Modeling cancer using patient-derived induced pluripotent stem cells to understand development of childhood malignancies.

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The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

http://www.wikidata.org/entity/Q40498073

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2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

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type

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The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

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prefLabel

The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

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The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

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Alexander Schramm

http://www.w3.org/2001/XMLSchema#string

Alvin Chan

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Angelika Eggert

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Arjan van Lakeman

http://www.w3.org/2001/XMLSchema#string

Huib Caron

http://www.w3.org/2001/XMLSchema#string

Max van Noesel

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Peter Sluis

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Vera van Limpt

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P2860

Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome

The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32

Molecular analysis of congenital central hypoventilation syndrome

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis.

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

A transcriptional repressor obtained by alternative translation of a trinucleotide repeat

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scholarly article

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10.1038/SJ.ONC.1208157

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23

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Rogier Versteeg

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