Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. - Wikidata - wikimedia - TriplyDB

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.

http://www.wikidata.org/entity/Q40501190

about

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment De-regulation of common housekeeping genes in hepatocellular carcinoma 7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes Targeting Pim kinases for cancer treatment: opportunities and challenges The PIM kinases in hematological cancers Pim-1 kinase as cancer drug target: An update Mutant FLT3 signaling contributes to a block in myeloid differentiation PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy Evidence that the Pim1 kinase gene is a direct target of HOXA9 Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability.Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.Ruthenium-based chemotherapeutics: are they ready for prime time?A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine Gene Expression and Serum Cytokine Profiling of Low Stage CLL Identify WNT/PCP, Flt-3L/Flt-3 and CXCL9/CXCR3 as Regulators of Cell Proliferation, Survival and Migration Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1.Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant Incorporating FLT3 inhibitors into acute myeloid leukemia treatment regimens.Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor.Cardiac progenitor cell cycling stimulated by pim-1 kinase Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development.Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade.Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition Hoxa9 and Flt3 signaling synergistically regulate an early checkpoint in lymphopoiesis.Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.

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P2860

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.

http://www.wikidata.org/entity/Q40501190

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Pim-1 is up-regulated by const ...... n FLT3-mediated cell survival.

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type

label

Pim-1 is up-regulated by const ...... n FLT3-mediated cell survival.

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Pim-1 is up-regulated by const ...... n FLT3-mediated cell survival.

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BLOOD-2004-05-2006

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Pim-1 is up-regulated by const ...... n FLT3-mediated cell survival.

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Donald Small

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Joon-Young Ahn

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Kristin Baird

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Kyu-Tae Kim

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Mark Levis

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Paul Meltzer

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1759-1767

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10.1182/BLOOD-2004-05-2006

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105

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15498859

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