Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.
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Analysis of RNA binding by the dengue virus NS5 RNA capping enzymeMolecular targets for flavivirus drug discoveryStructure and functionality in flavivirus NS-proteins: perspectives for drug designFunctional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityFlaviviral Replication Complex: Coordination between RNA Synthesis and 5'-RNA CappingProbing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptidesCleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile virusesEnzymatic Defects of the nsP2 Proteins of Semliki Forest Virus Temperature-Sensitive MutantsSwitching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based MutagenesisCrystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom ResolutionCrystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like ActivityCrystal Structure of the NS3 Protease-Helicase from Dengue VirusThe Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 HelicaseA complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replicationAnalysis of Flavivirus NS5 Methyltransferase Cap BindingThe flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structureCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationFocus on flaviviruses: current and future drug targetsFlexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implicationsAllosteric Inhibition of the NS2B-NS3 Protease from Dengue VirusSteady-state NTPase activity of Dengue virus NS3: number of catalytic sites, nucleotide specificity and activation by ssRNA.Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness.Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicaseFlaviviral RNAs: weapons and targets in the war between virus and host.The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replicationIdentification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replicationRNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.Fusion of protegrin-1 and plectasin to MAP30 shows significant inhibition activity against dengue virus replicationIdentification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus.A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral ReplicationAmodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity.Dengue virus nonstructural protein 5 adopts multiple conformations in solution.Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffoldDesign, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteasesCharacterization of 8-hydroxyquinoline derivatives containing aminobenzothiazole as inhibitors of dengue virus type 2 protease in vitroAn ATPase activity associated with the rotavirus phosphoprotein NSP5.Replication cycle and molecular biology of the West Nile virus.NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virusRegulation of flavivirus RNA synthesis and capping.
P2860
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P2860
Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Modulation of the nucleoside t ...... RNA-dependent RNA polymerase.
@en
type
label
Modulation of the nucleoside t ...... RNA-dependent RNA polymerase.
@en
prefLabel
Modulation of the nucleoside t ...... RNA-dependent RNA polymerase.
@en
P2093
P2860
P356
P1476
Modulation of the nucleoside t ...... e RNA-dependent RNA polymerase
@en
P2093
Changsuek Yon
Jessica Phelan
Krishna H M Murthy
R Padmanabhan
Tadahisa Teramoto
Vannakambadi K Ganesh
P2860
P304
27412-27419
P356
10.1074/JBC.M501393200
P407
P577
2005-05-24T00:00:00Z