ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining.
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ATR suppresses endogenous DNA damage and allows completion of homologous recombination repairATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2DNA repair targeted therapy: The past or future of cancer treatment?The DNA Damage Response: Making It Safe to Play with KnivesDNA damage response genes and the development of cancer metastasisThe effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joiningSelective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system developmentATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.A small peptide mimicking the key domain of MEPE/OF45 interacting with CHK1 protects human cells from radiation-induced killing.The Ku-dependent non-homologous end-joining pathway contributes to low-dose radiation-stimulated cell survival.EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.ATR contributes to telomere maintenance in human cellsDNA repair deficiency in neurodegeneration.Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteinsDICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27.Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell linesAlternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments.A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.Global chromatin compaction limits the strength of the DNA damage response.ATR signaling can drive cells into senescence in the absence of DNA breaks.The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation.ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.The ATR barrier to replication-born DNA damage.Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy.Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.DNA damage sensing by the ATM and ATR kinases.Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer.Molecular Pathways: Targeting ATR in Cancer TherapyChk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription.miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.Targeting radiation-resistant hypoxic tumour cells through ATR inhibitionAtaxia telangiectasia and rad3-related kinase contributes to cell cycle arrest and survival after cisplatin but not oxaliplatin.ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.
P2860
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P2860
ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
ATR affecting cell radiosensit ...... of nonhomologous end joining.
@en
type
label
ATR affecting cell radiosensit ...... of nonhomologous end joining.
@en
prefLabel
ATR affecting cell radiosensit ...... of nonhomologous end joining.
@en
P2093
P1433
P1476
ATR affecting cell radiosensit ...... of nonhomologous end joining.
@en
P2093
George Iliakis
Hongyan Wang
Huichen Wang
Simon N Powell
P304
P356
10.1158/0008-5472.CAN-04-1289
P407
P577
2004-10-01T00:00:00Z