The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
about
Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway.Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xLCyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.CDKN2A/p16 deletion in head and neck cancer cells is associated with Cdk2 activation, replication stress, and vulnerability to Chk1 inhibition.Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes.
P2860
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P2860
The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The fate of pancreatic tumor c ...... e modulation of CDK2 activity.
@en
type
label
The fate of pancreatic tumor c ...... e modulation of CDK2 activity.
@en
prefLabel
The fate of pancreatic tumor c ...... e modulation of CDK2 activity.
@en
P2093
P2860
P356
P1476
The fate of pancreatic tumor c ...... e modulation of CDK2 activity.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.CDD.4401481
P577
2004-10-01T00:00:00Z
P5875
P6179
1006882457