Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
about
Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cellsNkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cellsCancer gene therapy using a survivin mutant adenovirusBone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis.Anticancer drug targets: cell cycle and checkpoint control.Multiple functions of p27(Kip1) and its alterations in tumor cells: a review.Cell cycle and apoptosis.HTLV-I Tax related dysfunction of cell cycle regulators and oncogenesis of adult T cell leukemia.Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.Activity of the heat shock protein 90 inhibitor ganetespib in melanomaTargeting the cell cycle for cancer therapy.Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.Effects of STI571 and p27 gene clone on proliferation and apoptosis of K562 cells.P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori.CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaquesThe pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).Caspase-dependent Cdk activity is a requisite effector of apoptotic death events.Overexpression of p27(KIP1) induced cell cycle arrest in G(1) phase and subsequent apoptosis in HCC-9204 cell lineRNF135, RING finger protein, promotes the proliferation of human glioblastoma cells in vivo and in vitro via the ERK pathway.Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences.Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model.Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480.The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells.Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkI p27(KIP1) in transformed lymphoid cells.Mullerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism.p27KIP1 is down-regulated by two different mechanisms in human lymphoid cells undergoing apoptosis.Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation.CDKN1C (p57KIP2) mRNA expression in human retinoblastomas.Induction of cell cycle arrest and apoptosis in human prostate carcinoma cells by a recombinant adenovirus expressing p27(Kip1).Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors.Protection of renal cells from cisplatin toxicity by cell cycle inhibitors.Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo.Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions.Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo.Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth.Effects of adenovirus-mediated expression of p27Kip1, p21Waf1 and p16INK4A in cell lines derived from t(2;5) anaplastic large cell lymphoma and Hodgkin's disease.Glucocorticoid alternative effects on proliferating and differentiated mammary epithelium are associated to opposite regulation of cell-cycle inhibitor expression.
P2860
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P248
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P2860
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@ast
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en-gb
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@nl
type
label
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@ast
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en-gb
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@nl
prefLabel
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@ast
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en-gb
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@nl
P2093
P921
P356
P1433
P1476
Comparison of the effectivenes ...... d inhibition of tumorigenicity
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202466
P407
P577
1999-03-04T00:00:00Z
P5875
P6179
1027096073