Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics.
about
T cell antigen recognition at the cell membraneContribution of the CR domain to P-selectin lectin domain allostery by regulating the orientation of the EGF domainCadherin point mutations alter cell sorting and modulate GTPase signalingTwo stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region.Catch strip assay for the relative assessment of two-dimensional protein association kinetics.Action at a distance: lengthening adhesion bonds with poly(ethylene glycol) spacers enhances mechanically stressed affinity for improved vascular targeting of microparticlesEnhancement of L-selectin, but not P-selectin, bond formation frequency by convective flow.Visualization of allostery in P-selectin lectin domain using MD simulations.Mechanomics: an emerging field between biology and biomechanics.Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Biomechanics of leukocyte rollingT cells like a firm molecular handshake.P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces.Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domainProbabilistic modeling of rosette formation.Minimal encounter time and separation determine ligand-receptor binding in cell adhesionTransport governs flow-enhanced cell tethering through L-selectin at threshold shear.Determining beta2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay.Microcontact printing of P-selectin increases the rate of neutrophil recruitment under shear flow.Using engineered single-chain antibodies to correlate molecular binding properties and nanoparticle adhesion dynamics.Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-selectin on the cell membrane.Measuring diffusion and binding kinetics by contact area FRAP.Low spring constant regulates P-selectin-PSGL-1 bond ruptureTwo-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow.Rolling cell adhesion2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.Flow-Enhanced Stability of Rolling Adhesion through E-Selectin.Binding constants of membrane-anchored receptors and ligands: A general theory corroborated by Monte Carlo simulations.In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.Two-Dimensional Analysis of Cross-Junctional Molecular Interaction by Force Probes.The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.Adhesion frequency assay for in situ kinetics analysis of cross-junctional molecular interactions at the cell-cell interface.Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.Developing a microfluidic-based system to quantify cell capture efficiency.Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands.Affinity and kinetic analysis of Fcgamma receptor IIIa (CD16a) binding to IgG ligands.The glycocalyx promotes cooperative binding and clustering of adhesion receptors.
P2860
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P2860
Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Quantifying the effects of mol ...... eptor-ligand binding kinetics.
@en
type
label
Quantifying the effects of mol ...... eptor-ligand binding kinetics.
@en
prefLabel
Quantifying the effects of mol ...... eptor-ligand binding kinetics.
@en
P2093
P2860
P356
P1476
Quantifying the effects of mol ...... eptor-ligand binding kinetics.
@en
P2093
Padmaja Mehta
Rodger P McEver
Scott E Chesla
Tadayuki Yago
P2860
P304
44915-44923
P356
10.1074/JBC.M407039200
P407
P577
2004-08-06T00:00:00Z