BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo.
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Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Cancer therapies utilizing the camptothecins: a review of the in vivo literatureTopoisomerases: Resistance versus Sensitivity, How Far We Can Go?An overview of quinoline as a privileged scaffold in cancer drug discovery.Synthesis and biological evaluation of 7-alkenyl homocamptothecins as potent topoisomerase I inhibitors.Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase I inhibitors.Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors.Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors.
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BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo.
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2004 nî lūn-bûn
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2004年の論文
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name
BN80927: a novel homocamptothe ...... or cells in vitro and in vivo.
@en
type
label
BN80927: a novel homocamptothe ...... or cells in vitro and in vivo.
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prefLabel
BN80927: a novel homocamptothe ...... or cells in vitro and in vivo.
@en
P2093
P1433
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BN80927: a novel homocamptothe ...... or cells in vitro and in vivo.
@en
P2093
Danièle Demarquay
Dennis C H Bigg
Grégoire Prévost
Helène Coulomb
José Camara
Laurence Lesueur-Ginot
Marion Huchet
Olivier Lavergne
Philip G Kasprzyk
P304
P356
10.1158/0008-5472.CAN-03-3872
P407
P577
2004-07-01T00:00:00Z