Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60.
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Quantitative modeling of selective lysosomal targeting for drug designRetromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in DrosophilaBioanalysis of eukaryotic organellesLysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitroDerivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplersSimulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines.Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells.Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction.Cellular uptake and internalization of hyaluronan-based doxorubicin and cisplatin conjugatesIn Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383[¹¹C]Rhodamine-123: synthesis and biodistribution in rodents.Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic fluxAssessment of golgi apparatus versus plasma membrane-localized multi-drug resistance-associated protein 1Screening for the drug-phospholipid interaction: correlation to phospholipidosis.Optimal choice of pH for toxicity and bioaccumulation studies of ionizing organic chemicals.From serendipity to mitochondria-targeted nanocarriers.Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications.Lysosomal Biology in Cancer.Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance.Evaluation of two (125)I-radiolabeled acridine derivatives for Auger-electron radionuclide therapy of melanoma.Retaining cytotoxic activity of anthrapyridone CO1 against multidrug resistant cells is related to the ability to induce concomitantly apoptosis and lysosomal death of leukaemia HL60/VINC and HL60/DOX cells.Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification.A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration.Niemann-Pick C1 functions in regulating lysosomal amine content.Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.Blocking of Single α-Hemolysin Pore by Rhodamine Derivatives.LysoTracker and MitoTracker Red are transport substrates of P-glycoprotein: implications for anticancer drug design evading multidrug resistance.Modifications in Human Oral Fibroblast Ultrastructure, Collagen Production, and Lysosomal Compartment in Response to Electronic Cigarette Fluids.Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis elegans.Electrophoretic mobility measurements of fluorescent dyes using on-chip capillary electrophoresis.Electrogenic proton transport across lipid bilayer membranes mediated by cationic derivatives of rhodamine 19: comparison with anionic protonophores.
P2860
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P2860
Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Weak base permeability charact ...... uman leukemic cell line HL-60.
@en
type
label
Weak base permeability charact ...... uman leukemic cell line HL-60.
@en
prefLabel
Weak base permeability charact ...... uman leukemic cell line HL-60.
@en
P2093
P2860
P356
P1476
Weak base permeability charact ...... uman leukemic cell line HL-60.
@en
P2093
Dev Chatterji
Jeffrey P Krise
Muralikrishna Duvvuri
Yuping Gong
P2860
P304
32367-32372
P356
10.1074/JBC.M400735200
P407
P577
2004-06-03T00:00:00Z