Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor.
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Physiology of the orexinergic/hypocretinergic system: a revisit in 20123D structure prediction of human β1-adrenergic receptor via threading-based homology modeling for implications in structure-based drug designingStructural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations.Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay.Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.Kinin-stimulated B1 receptor signaling depends on receptor endocytosis whereas B2 receptor signaling does not.Regulation of G protein-coupled receptor export trafficking.Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptorsHallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors.Potential roles of the prokineticins in reproductionArrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.Regulation of anterograde transport of alpha2-adrenergic receptors by the N termini at multiple intracellular compartments.Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.Illuminating the life of GPCRsThe second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression.Inhibition of sequestration of human B2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells.Helix 8 plays a crucial role in bradykinin B(2) receptor trafficking and signaling.Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.A common intracellular allosteric binding site for antagonists of the CXCR2 receptor.C-terminal fusion of eGFP to the bradykinin B2 receptor strongly affects down-regulation but not receptor internalization or signaling.Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs.Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist.Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation.Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR.Signalling properties and pharmacology of a 5-HT7 -type serotonin receptor from Tribolium castaneum.
P2860
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P2860
Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Mutation of tyrosine in the co ...... human B2 bradykinin receptor.
@en
type
label
Mutation of tyrosine in the co ...... human B2 bradykinin receptor.
@en
prefLabel
Mutation of tyrosine in the co ...... human B2 bradykinin receptor.
@en
P2093
P2860
P356
P1476
Mutation of tyrosine in the co ...... human B2 bradykinin receptor.
@en
P2093
Alexander Faussner
Andree Blaukat
David Proud
Irina Kalatskaya
Marianne Jochum
Steffen Schüssler
P2860
P304
31268-31276
P356
10.1074/JBC.M401796200
P407
P577
2004-05-25T00:00:00Z