Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities.
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Modulating splicing with small molecular inhibitors of the spliceosomeMicrobial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer TreatmentThe splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.A synthetic entry to pladienolide B and FD-895Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.A new chitinase-producer strain Streptomyces glauciniger WICC-A03: isolation and identification as a biocontrol agent for plants phytopathogenic fungi.A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomesNatural products to drugs: natural product-derived compounds in clinical trials.Radiosynthesis of antitumor spliceosome modulators.High antitumor activity of pladienolide B and its derivative in gastric cancerDesign, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.Identification of small molecule inhibitors of pre-mRNA splicing.Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A.Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitorSmall Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyRuthenium-Catalyzed Olefin Metathesis after Tetra-n-butylammonium Fluoride-Mediated Desilylation.Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stagesGenome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5AGenomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43The spliceosome as target for anticancer treatment.Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system.Natural product mode of action (MOA) studies: a link between natural and synthetic worlds.Splicing in oncogenesis and tumor suppression.Pre-mRNA splicing in disease and therapeutics.The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues.Therapeutic targeting of splicing in cancer.Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucomaRNA processing as an alternative route to attack glioblastoma.Biological validation that SF3b is a target of the antitumor macrolide pladienolide.Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.
P2860
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P2860
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Pladienolides, new substances ...... in vivo antitumor activities.
@en
type
label
Pladienolides, new substances ...... in vivo antitumor activities.
@en
prefLabel
Pladienolides, new substances ...... in vivo antitumor activities.
@en
P2093
P1476
Pladienolides, new substances ...... in vivo antitumor activities.
@en
P2093
Hajime Shimizu
Kentaro Yoshimatsu
Kiyoshi Okamoto
Makoto Asada
Masao Iwata
Takao Yamori
Takashi Sakai
Toshimitsu Uenaka
Yoshiharu Mizui
P304
P356
10.7164/ANTIBIOTICS.57.188
P577
2004-03-01T00:00:00Z