Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.
about
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinilBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesRole of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuseRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterClassic Studies on the Interaction of Cocaine and the Dopamine TransporterDopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood.A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine.Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental studyMutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelSLC6 transporters: structure, function, regulation, disease association and therapeuticsSite-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transportersInteraction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamineDopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinitiesFluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter.Monoamine transporters: vulnerable and vital doorkeepers.How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation.Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.Importance of cholesterol in dopamine transporter function.Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding.Substrates dissociate dopamine transporter oligomers.Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia.Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells.Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain.Computational modeling of human dopamine transporter structures, mechanism and its interaction with HIV-1 transactivator of transcription.Impact of disruption of secondary binding site S2 on dopamine transporter function.A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants.Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter.Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulationsSubstrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells.The role of human dopamine transporter in NeuroAIDS.Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons.The dopamine uptake inhibitor 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward.Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.
P2860
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P2860
Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Mutation of Trp84 and Asp313 o ...... tropine as opposed to cocaine.
@en
type
label
Mutation of Trp84 and Asp313 o ...... tropine as opposed to cocaine.
@en
prefLabel
Mutation of Trp84 and Asp313 o ...... tropine as opposed to cocaine.
@en
P2860
P1476
Mutation of Trp84 and Asp313 o ...... ztropine as opposed to cocaine
@en
P2093
Maarten E A Reith
Nianhang Chen
P2860
P304
P356
10.1111/J.1471-4159.2004.02386.X
P407
P50
P577
2004-05-01T00:00:00Z