Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.
about
X-ray structure of dopamine transporter elucidates antidepressant mechanismR-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuseThe binding sites for cocaine and dopamine in the dopamine transporter overlapNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesRole of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuseRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterAn N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporterConformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocationThe N terminus of monoamine transporters is a lever required for the action of amphetaminesAllosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.SLC6 family transporter SNF-10 is required for protease-mediated activation of sperm motility in C. elegansMutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport.N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effectsMutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelConformationally sensitive proximity of extracellular loops 2 and 4 of the γ-aminobutyric acid (GABA) transporter GAT-1 inferred from paired cysteine mutagenesisSite-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transportersInteraction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium SymportersThe stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter.Importance of cholesterol in dopamine transporter function.Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding.Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine UptakeThe binding sites for benztropines and dopamine in the dopamine transporter overlap.Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization.Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change.The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transportCtr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane.Impact of disruption of secondary binding site S2 on dopamine transporter function.Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer.
P2860
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P2860
Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Generation of an activating Zn
@nl
Generation of an activating Zn ...... ibrium of the transport cycle.
@ast
Generation of an activating Zn ...... ibrium of the transport cycle.
@en
type
label
Generation of an activating Zn
@nl
Generation of an activating Zn ...... ibrium of the transport cycle.
@ast
Generation of an activating Zn ...... ibrium of the transport cycle.
@en
prefLabel
Generation of an activating Zn
@nl
Generation of an activating Zn ...... ibrium of the transport cycle.
@ast
Generation of an activating Zn ...... ibrium of the transport cycle.
@en
P2093
P2860
P356
P1476
Generation of an activating Zn ...... ibrium of the transport cycle.
@en
P2093
Claus Juul Loland
Lene Norregaard
Thomas Litman
Ulrik Gether
P2860
P304
P356
10.1073/PNAS.032386299
P407
P577
2002-01-29T00:00:00Z