In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinase.
about
A viral cleavage site cassette: identification of amino acid sequences required for tobacco etch virus polyprotein processingSimple in vitro translation assay to analyze inhibitors of rhinovirus proteasesEvidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyproteinThe picornaviral 3C proteinases: cysteine nucleophiles in serine proteinase folds.A second proteinase encoded by a plant potyvirus genome.Cleavage-site preferences of Sindbis virus polyproteins containing the non-structural proteinase. Evidence for temporal regulation of polyprotein processing in vivo.SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavageModulation of poliovirus replicative fitness in HeLa cells by deoptimization of synonymous codon usage in the capsid region.Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad.Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinasesMinimum internal ribosome entry site required for poliovirus infectivityA cellular cofactor facilitates efficient 3CD cleavage of the poliovirus P1 precursor.Proteolytic activity of hepatitis A virus 3C proteintrans rescue of a mutant poliovirus RNA polymerase functionAlternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus.Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter.cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication.Proteolytic cleavage of encephalomyocarditis virus capsid region substrates by precursors to the 3C enzyme.Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirus.Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase.Chimeric picornavirus polyproteins demonstrate a common 3C proteinase substrate specificityEffects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage.Inducible expression of encephalomyocarditis virus 3C protease activity in stably transformed mouse cell linesPolyprotein processing of Theiler's murine encephalomyelitis virus.Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virusMutational analysis of tobacco etch virus polyprotein processing: cis and trans proteolytic activities of polyproteins containing the 49-kilodalton proteinase.An internal 5'-noncoding region required for translation of poliovirus RNA in vitroMutational analysis of the genome-linked protein VPg of poliovirus.Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing.Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.Processing determinants required for in vitro cleavage of the poliovirus P1 precursor to capsid proteins.Site-specific mutations at a picornavirus VP3/VP1 cleavage site disrupt in vitro processing and assembly of capsid precursorsExpression of virus-encoded proteinases: functional and structural similarities with cellular enzymesConstruction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutantsDefective RNA replication by poliovirus mutants deficient in 2A protease cleavage activityLinker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA.Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNAMultiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides.
P2860
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P2860
In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinase.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
In vitro molecular genetics as ...... the poliovirus 3C proteinase.
@en
type
label
In vitro molecular genetics as ...... the poliovirus 3C proteinase.
@en
prefLabel
In vitro molecular genetics as ...... the poliovirus 3C proteinase.
@en
P2860
P356
P1476
In vitro molecular genetics as ...... the poliovirus 3C proteinase.
@en
P2093
B L Semler
M F Ypma-Wong
P2860
P304
P356
10.1093/NAR/15.5.2069
P577
1987-03-01T00:00:00Z