BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint.
about
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsCdc7-Dbf4 and the human S checkpoint response to UVCKinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitorsNovel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death thresholdImproving detection of differentially expressed gene sets by applying cluster enrichment analysis to Gene Ontology.BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemiaRegulation and roles of Cdc7 kinase under replication stress.Loss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint controlThe role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitorsDbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Checking on DNA damage in S phase.Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joiningSrc kinases as targets for B cell acute lymphoblastic leukaemia therapy.Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells.Cell cycle regulation of DNA replication.Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemiaApplying the discovery of the Philadelphia chromosome.Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.Management of the advanced phases of chronic myelogenous leukemia in the era of tyrosine kinase inhibitors.Tumor suppressor genes in myeloid differentiation and leukemogenesis.Signaling networks associated with BCR-ABL-dependent transformation.The human intra-S checkpoint response to UVC-induced DNA damage.Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia.BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia.Anti-Proliferative Effects of Dendrophthoe pentandra Methanol Extract on BCR/ABL-Positive and Imatinib-Resistant Leukemia Cell LinesATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stressInhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia.Molecular architecture of the DNA replication origin activation checkpoint.Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling.Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance.Identification of TopBP1 as a c-Abl-interacting protein and a repressor for c-Abl expression.Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.Drug design with Cdc7 kinase: a potential novel cancer therapy target.BRIT1/MCPH1 expression in chronic myeloid leukemia and its regulation of the G2/M checkpoint.Genomic instability in chronic myeloid leukemia: targets for therapy?
P2860
Q24670609-08A2931E-696B-46AB-B81E-5F163AE0CF4FQ24672815-AF84F040-02F1-4202-A9C2-7251E6108513Q26849792-78310E69-836A-4A36-8D07-94344958AD2EQ27932610-C2CBF15E-912A-4CEA-A202-9755EBE0FCB2Q28704493-263705EF-2736-4B17-BA63-DBCBB2C7C918Q33490282-CC30B487-0860-43E0-B98C-FA6F4760B3EDQ33796384-0EA7F220-3B73-465B-890A-E425548B73D4Q33913826-8A78A9E5-EDF5-45A6-AED2-8C9E60B671E8Q33953075-426CD662-E695-4C1B-9508-CC2090C99A4AQ34170428-025EC344-2A20-4FC8-91FC-0C6A34290B0BQ34911467-955FF070-FFA5-403D-898F-4E6F1D3A9F39Q35459748-DF9C0259-F362-4D9F-8D9C-0C7B2813382EQ35709940-76618B39-12D3-4557-9989-E9946E75DD96Q35906070-9EA09A12-A595-44E3-8ECD-186158E010FAQ36058572-67B78FE9-E52C-40BD-83E6-048A02C66D8AQ36150854-A446A97C-24FC-4063-B353-0253FD2AE088Q36398134-03E853B1-ACE0-4F13-8337-2D9C12BFB057Q36881426-D674351F-55B4-47C1-A12D-1154BA8D6CA7Q36883073-742C0305-2BEA-4E6E-8D66-EA7A931804C5Q36900109-7B0ACA1D-7420-443C-9AD2-F4B5F8931B48Q37148115-C5C0ECCB-B358-4DCD-9DC7-4642356FE4F0Q37334605-CB4FDB34-AACF-4A32-B746-561749421439Q37360559-98C172C7-96AB-404F-845A-D63CCE8A8136Q37414369-3B0A9288-1DDB-460B-BCD5-AEEBCEC2F06DQ37428655-43785CD6-02B2-4291-B056-A5D9023767F2Q37606136-3CE7A2C4-A7EB-442C-B42B-5A2DC81DC2C9Q37688465-41E60328-D2D0-4185-B981-ABCD362F5363Q37743173-8A7AC1F3-F37C-453A-9C9F-8F38626EEFDCQ38723954-F1CA7D4C-04B6-4787-9C36-2D35FD5B9889Q39062429-94FC43EC-FD71-4C1D-8539-82A24DDAA3B7Q39259207-358B33F8-F602-42D9-A113-6716B2F88BB0Q39433276-698848E7-800F-4D8A-85AA-7BD970509085Q39664689-F5471ED5-B24E-4D53-B71E-CE676B964D52Q40120694-BE77FAB1-EE24-47A8-B888-19352262D6ADQ40314843-7CA8E14F-C161-499F-A353-E309654DC2C7Q40408492-4A1F6F17-2C7C-4C71-A198-C50FF0850118Q41809632-EE17FCEE-12C7-49A7-8BD4-C3C6C3385F1EQ42582777-D7E3949D-E70C-4341-8A36-E4E2220765D3Q53218157-59E1AE62-1237-4E49-90C0-27DC7A246BDFQ53272675-0255F31B-D4B3-45AC-BAE5-3FE03330AFEA
P2860
BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
BCR/ABL translocates to the nu ...... dent intra-S phase checkpoint.
@en
type
label
BCR/ABL translocates to the nu ...... dent intra-S phase checkpoint.
@en
prefLabel
BCR/ABL translocates to the nu ...... dent intra-S phase checkpoint.
@en
P2093
P1433
P1476
BCR/ABL translocates to the nu ...... dent intra-S phase checkpoint.
@en
P2093
Jamil Dierov
Martin Carroll
Raia Dierova
P304
P356
10.1016/S1535-6108(04)00056-X
P577
2004-03-01T00:00:00Z