Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
about
Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}.Culture of K562 human myeloid leukemia cells in presence of fibronectin expresses and secretes MMP-9 in serum-free culture medium.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationDual inhibition of epidermal growth factor receptor and insulin-like growth factor receptor I: reduction of angiogenesis and tumor growth in cutaneous squamous cell carcinoma.Inhibitory effects of corni fructus extract on angiogenesis and adipogenesis.Hydrogen sulphide decreases IL-1β-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis.Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily.p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodelingMetformin inhibits the proliferation of benign prostatic epithelial cellsPRL-3 activates mTORC1 in Cancer Progression.MMP2 and MMP7 at the invasive front of gastric cancer are not associated with mTOR expressionExtracellular influences on tumour angiogenesis in the aged host.AKT2 confers protection against aortic aneurysms and dissections.Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling.High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice.Irs2 inactivation suppresses tumor progression in Pten+/- mice.TFPI-2 silencing increases tumour progression and promotes metalloproteinase 1 and 3 induction through tumour-stromal cell interactions.The effects of interleukin-1β in modulating osteoclast-conditioned medium's influence on gelatinases in chondrocytes through mitogen-activated protein kinases.The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases.Targeted therapy in nonmelanoma skin cancers.H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury.Downregulation of cancer stem cell properties via mTOR signaling pathway inhibition by rapamycin in nasopharyngeal carcinoma.Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells.Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/β-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect.Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor.Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways.The effect of TGF-beta2 on MMP-2 production and activity in highly metastatic human bladder carcinoma cell line 5637.Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors.Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells.Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1Curcumin treatment alters ERK-1/2 signaling in vitro and inhibits nasopharyngeal carcinoma proliferation in mouse xenografts.Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion.IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin.Inhibition of Necl-5 (CD155/PVR) reduces glioblastoma dispersal and decreases MMP-2 expression and activity.Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts.
P2860
Q26827810-EDAD2E3A-AB1D-43C5-AC62-DB1DFC1F46AAQ30423008-B9ADFEFF-1BAB-458F-ACBF-08FDFE9BE531Q33642028-CFFD2931-2084-4328-A6CA-7B84DFF37DE5Q33719178-5BA367EB-3BD5-44B6-B852-6AC6B6D90C85Q34387886-FE5B813F-340D-4403-BB17-B8124AD16470Q34442002-F5E66BDA-02F3-47CC-A47C-C8A45ACE710FQ34706130-0D2B89DA-6412-4E37-A78B-0FB25BAD69A5Q34885481-8842EA79-0120-4875-98D5-DF2FC295E22DQ35221813-6605CC9F-B7AA-4927-9D63-355B99A7515DQ35598268-B8673B2D-0B83-4E3F-86A8-92194B152197Q36295425-3EA33420-EDBE-4674-9AFC-157DD5278B4AQ36310169-70B24604-8A12-4FD8-86A1-4E5BE98DDC01Q36366058-BE32FDEB-D710-47A5-A4AF-C83D6916FE03Q36614769-2FB57173-04CB-42D6-8D9F-67F15C0D6A2BQ36650845-B9FD8423-CB3F-44F0-8CBF-D76A32C5DA1AQ36650919-1F6E7E1F-2DB8-45A0-A97E-06A45130AC2CQ36956086-5DDEA798-8B6F-4BB8-BB8F-D9C4AB712F31Q37073819-6A9A9F3B-4ECB-4861-859C-2D111AA6B5B5Q37294488-BDF271A0-F479-4D7E-BAC0-CE42CF567528Q37497410-5DB98233-6F89-46BE-BB5B-6B164CB2C5AAQ37536351-2DA2132F-AB36-48BA-A3B5-C59EBDDCB746Q37769281-0098BDBE-C03E-4993-B622-E24C7D647184Q38161358-DC44C533-3A27-4B21-92D9-1BCD399F221DQ38515287-4675BF74-A485-4BF2-B0BB-571CB7D356B7Q38837461-904D31A6-4DF6-4FAD-9BF9-7F71DC1FBC3DQ38850277-F1D1BB94-9025-4A21-B166-A22E960B169BQ38870573-E15BEF76-D615-4AF4-80C7-42A05D17E10DQ39045827-6BCADA97-A2D9-49FC-987F-CDB35F09006BQ39169837-37BD8E35-3254-42CA-94AA-0A6104C1B2AFQ39700912-3FEDDACA-A7BA-4F94-9809-C5EA6F09DF38Q39883545-526853FF-AE86-414E-97D0-1C51FDA0E478Q39940514-2751CD88-DDCE-457E-A8D3-3C4459DA0E5CQ40116086-2A9D724F-3CC5-42F9-95E7-03D2EC89A3A9Q41701136-2D2290CA-964B-43CB-9F27-396CED621C78Q41891609-4E9A8D27-CBA8-44A1-BB21-46DF0629E1C1Q42119362-58B1387A-1A6E-47EB-A6BD-98D55C0190B7Q42206973-217C2BD9-1FE3-4C4F-A748-C84338477607Q42322249-136AC2E5-4D6D-4872-A305-55C7823060D4Q42475272-C63A5E5F-A9C3-43AA-B97D-4F8376DE6184Q42908910-69FA2B35-A399-4045-BD2F-757AC313F68D
P2860
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Dual regulation of MMP-2 expre ...... ays transmit opposing signals.
@en
type
label
Dual regulation of MMP-2 expre ...... ays transmit opposing signals.
@en
prefLabel
Dual regulation of MMP-2 expre ...... ays transmit opposing signals.
@en
P2093
P2860
P356
P1476
Dual regulation of MMP-2 expre ...... ays transmit opposing signals.
@en
P2093
Donglei Zhang
Menashe Bar-Eli
Pnina Brodt
Sylvain Meloche
P2860
P304
19683-19690
P356
10.1074/JBC.M313145200
P407
P577
2004-03-01T00:00:00Z