Irs2 inactivation suppresses tumor progression in Pten+/- mice. - Wikidata - wikimedia - TriplyDB

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

http://www.wikidata.org/entity/Q37073819

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The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins Genetic variants in CASP3, BMP5, and IRS2 genes may influence survival in prostate cancer patients receiving androgen-deprivation therapy IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer.Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.Expression and function of the insulin receptor substrate proteins in cancer Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion.miR-106a* inhibits the proliferation of renal carcinoma cells by targeting IRS-2.MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells.Regulation of the tumor suppressor PTEN by natural anticancer compounds.The influence of growth hormone/insulin-like growth factor deficiency on prostatic dysplasia in pbARR2-Cre, PTEN knockout mice.IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

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Irs2 inactivation suppresses tumor progression in Pten+/- mice.

http://www.wikidata.org/entity/Q37073819

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 December 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

@en

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

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type

label

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

@en

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

@nl

prefLabel

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

@en

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

@nl

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AJPATH.2009.080086

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The American Journal of Pathology

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Irs2 inactivation suppresses tumor progression in Pten+/- mice.

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Giselle Davidian

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Jake A Kushner

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Latarsha J Reid

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Laura Simpson

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Matthias Szabolcs

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Megan Keniry

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Morris F White

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Ramon Parsons

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Sarah C Schiff

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Scott Licata

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P2860

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

High frequency of mutations of the PIK3CA gene in human cancers

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

Non-transcriptional control of DNA replication by c-Myc

Pten is essential for embryonic development and tumour suppression

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276-286

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scholarly article

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10.2353/AJPATH.2009.080086

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Argiris Efstratiadis

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