The signaling adapter protein DAP12 regulates multinucleation during osteoclast development.
about
Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure.Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor.CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritisOsteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal boneMyeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritisDAP12: an adapter protein with dual functionality.DAP12 overexpression induces osteopenia and impaired early hematopoiesis.Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats.Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages.Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice.The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption.Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory diseaseRNA therapeutics targeting osteoclast-mediated excessive bone resorption.The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.E proteins regulate osteoclast maturation and survival.Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender.The TREM receptor family and signal integration.The SYK tyrosine kinase: a crucial player in diverse biological functions.Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisTREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.DAP10- and DAP12-associated receptors in innate immunity.Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice.A potential role of myeloid DAP12-associating lectin (MDL)-1 in the regulation of inflammation in rheumatoid arthritis patients.The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.Osteoimmunology: the expanding role of immunoreceptors in osteoclasts and bone remodelingA Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.TREM2 in Neurodegenerative Diseases.DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-cateninEnhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation.Crosstalk among IL-23 and DNAX activating protein of 12 kDa-dependent pathways promotes osteoclastogenesisEos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.Editorial: lipid kinases and bone homeostasis: lessons learned from phosphoinositide 3-kinase isoform-specific knockouts.
P2860
Q28590300-10086DE1-AC91-48D0-BA9E-3413C2CE1A23Q28594672-61951BFF-AC81-4705-BCC5-7C77C13BF2BFQ33289958-23B01370-000F-4DB2-AB28-072F20190502Q33820660-CE139D67-3568-4C67-8461-B02519C0A822Q33873672-0FB37A6E-15D2-4848-A9E2-6E8DF1CFA8EEQ34000267-23AB69B1-5897-4246-8446-FCA5CE1184EDQ34102750-32DB06AB-96D5-4640-A67C-F0006A781FAAQ34581211-CC9F1BB1-FB7E-4E79-B28E-25079DA36CFAQ34775668-828CE1C2-3AF1-438F-A8C1-3163B3FA080EQ34950018-17F8D386-3ECF-4DCD-837A-54BD4C25B690Q35083498-253ECD8C-5C61-43AA-81F2-F3629DA81C34Q35634073-BCF6D216-8BD9-4049-B229-BE5ADA29DA38Q35640941-E4892229-8603-4336-BFEC-F7670EC5DA2CQ35697027-35CC0572-F2AD-4A60-BC21-1353E9907BEFQ35754345-636150AE-774B-4A04-9702-00CA79CC9A8CQ35800463-F708ADE1-8D9C-4C2C-90AE-0F0380155EC2Q36161131-D5401E5D-5C37-4294-9664-CB530AFDB788Q36390005-29D1A3DE-3D61-40EF-AB96-C8C1972F7F58Q36544723-502E9108-87C5-49B8-AB02-D9173C3165A7Q36655903-3AFB98BD-F945-4DCA-AFC6-13E65074DC5BQ36662082-8DC0E95E-6E22-4792-B864-B87C614E4419Q36944827-EF8876F9-B763-4F65-81A8-26C05E7D8D0CQ37066493-2CBC0A43-7315-4695-81C6-01A58443BD49Q37171072-4F67D2E0-1248-4A4D-8948-C16C1F109FCEQ37361459-F3E034F0-8BF8-4816-80AD-B479130D2FBFQ37482220-662A60A0-CCEB-40DA-BE84-90021EF27D0BQ37500085-43C9F00D-C0F9-4A1C-A537-AEF181291579Q37647341-DF9FD869-5D99-444F-B3C3-F0F5FD561989Q38116019-85CC24E9-627B-452E-BDB8-91503D3D09C5Q38634916-04B36ACA-272F-4C50-AF15-465C1062B56AQ38646212-FC1CACA1-4FF1-4E88-9EDE-788AFF01B9CFQ38709277-122055C1-FA0A-4F1C-8AA2-28FAA7547A19Q38744013-701BE445-7686-43F0-BF47-C43CC70C0F56Q39064440-46B4BD92-6F75-4350-A9A7-5E692D7A48D6Q39669362-85068E92-99CD-4F21-B2D9-17BC5B823C84Q39702429-EE2B6CDD-9A3A-4DBB-B06A-D342998CB021Q40617973-CDBF46AA-2AE1-4BAB-B5B5-C7A3F2AFF2BDQ41752189-782C9A7D-2A49-4695-B921-27F2E14E99BCQ41842422-6658577B-E444-4700-B42D-6E6048EC0FE5Q42398103-49E04BC5-B8EA-4C80-805B-1A5851A7001E
P2860
The signaling adapter protein DAP12 regulates multinucleation during osteoclast development.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The signaling adapter protein ...... during osteoclast development.
@en
type
label
The signaling adapter protein ...... during osteoclast development.
@en
prefLabel
The signaling adapter protein ...... during osteoclast development.
@en
P2093
P2860
P356
P1476
The signaling adapter protein ...... during osteoclast development.
@en
P2093
Kouetsu Ogasawara
Lewis L Lanier
Mary Beth Humphrey
Mary C Nakamura
Michael R Daws
Nancy E Lane
Steven C Spusta
P2860
P304
P356
10.1359/JBMR.0301234
P577
2003-12-16T00:00:00Z