Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.
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Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factorBile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell modelsHIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).Detecting cancer gene networks characterized by recurrent genomic alterations in a population.Regulation of HIF-1alpha stability through S-nitrosylation.Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluationStructural basis for depletion of heat shock protein 90 client proteins by deguelin.Emetine promotes von Hippel-Lindau-independent degradation of hypoxia-inducible factor-2α in clear cell renal carcinoma.The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation.Impact of heat-shock protein 90 on cancer metastasisCloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxiaKruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endotheliumRegulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase.Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.Non-hypoxic transcriptional activation of the aryl hydrocarbon receptor nuclear translocator in concert with a novel hypoxia-inducible factor-1alpha isoform.FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.The metabolic switch and its regulation in cancer cells.The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei.RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT.Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation.Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.
P2860
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P2860
Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Aryl hydrocarbon nuclear trans ...... -dependent regulatory pathway.
@en
type
label
Aryl hydrocarbon nuclear trans ...... -dependent regulatory pathway.
@en
prefLabel
Aryl hydrocarbon nuclear trans ...... -dependent regulatory pathway.
@en
P2093
P2860
P356
P1476
Aryl hydrocarbon nuclear trans ...... -dependent regulatory pathway.
@en
P2093
Jennifer S Isaacs
Len Neckers
Yun-Jin Jung
P2860
P304
16128-16135
P356
10.1074/JBC.M313342200
P407
P577
2004-02-05T00:00:00Z