Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. - Wikidata - wikimedia - TriplyDB

Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.

Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.

http://www.wikidata.org/entity/Q40609797

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Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells Advances in Lipidomics for Cancer Biomarkers Discovery Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression Exocrine pancreatic carcinogenesis and autotaxin expression Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device.Role of malignant ascites on human mesothelial cells and their gene expression profiles Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling.LPA receptor signaling: pharmacology, physiology, and pathophysiology.Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients.Krüppel-like factor 4 mediates lysophosphatidic acid-stimulated migration and proliferation of PC3M prostate cancer cells.Lysophospholipid receptor nomenclature review: IUPHAR Review 8.Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma.The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.Molecular regulation of lysophosphatidic acid receptor 1 trafficking to the cell surface.Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein Mitogenic Signaling by the gep Oncogene Involves the Upregulation of S-Phase Kinase-Associated Protein 2.Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Targeted ovarian cancer treatment: the TRAILs of resistance.Inflammation-regulating factors in ascites as predictive biomarkers of drug resistance and progression-free survival in serous epithelial ovarian cancers Expression of lysophosphatidic acid receptors and local invasiveness and metastasis in Chinese pancreatic cancers.Profiling of cytokines in human epithelial ovarian cancer ascites.Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid.The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis Inhibition of lysophosphatidic acid receptor-2 expression by RNA interference decreases lysophosphatidic acid-induced urokinase plasminogen activator activation, cell invasion, and migration in ovarian cancer SKOV-3 cells.The gep proto-oncogene Gα13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells.Anastellin, the angiostatic fibronectin peptide, is a selective inhibitor of lysophospholipid signaling.Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21.

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P2860

Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.

http://www.wikidata.org/entity/Q40609797

description

2003 nî lūn-bûn

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Lysophosphatidic acid (LPA) in ...... tic cancer cells through LPA1.

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Lysophosphatidic acid (LPA) in ...... tic cancer cells through LPA1.

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Lysophosphatidic acid (LPA) in ...... tic cancer cells through LPA1.

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Journal of Biological Chemistry

P1476

Lysophosphatidic acid (LPA) in ...... tic cancer cells through LPA1.

@en

P2093

Atsushi Kuwabara

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Doon-Soon Im

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Enkhzol Malchinkhuu

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Fumikazu Okajima

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Hideaki Tomura

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Hideo Ohta

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Koichi Sato

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Koichi Tamoto

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Masayuki Tobo

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Mayumi Komachi

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P2860

The Hallmarks of Cancer

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Gleevec (STI-571) inhibits lung cancer cell growth (A549) and potentiates the cisplatin effect in vitro

Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family

Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1

Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells

Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane.

Bioactive lysophospholipids and their G protein-coupled receptors.

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

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6595-6605

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10.1074/JBC.M308133200

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8

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279

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2003-12-03T00:00:00Z

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14660630

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