Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model.
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Histone deacetylase 6 interacts with the microtubule-associated protein tauPhysiological and pathological phosphorylation of tau by Cdk5Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse ModelsThe frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.Truncated tau and Aβ cooperatively impair mitochondria in primary neurons.Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer diseaseThe Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease.Protein phosphorylation in neurodegeneration: friend or foe?Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant TauAccumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic miceExpression of Tau Produces Aberrant Plasma Membrane Blebbing in Glial Cells Through RhoA-ROCK-Dependent F-Actin Remodeling.The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.Oxidative stress mediates tau-induced neurodegeneration in DrosophilaQuantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro.Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death.FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells.On-chip microtubule gliding assay for parallel measurement of tau protein species.Hydration-sensitive gene expression in brain.Family-based association analysis of the MAPT gene in Parkinson disease.
P2860
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P2860
Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model.
description
2003 nî lūn-bûn
@nan
2003年の論文
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2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
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2003年论文
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name
Mutant (R406W) human tau is hy ...... neuronal cortical cell model.
@en
type
label
Mutant (R406W) human tau is hy ...... neuronal cortical cell model.
@en
prefLabel
Mutant (R406W) human tau is hy ...... neuronal cortical cell model.
@en
P2860
P356
P1476
Mutant (R406W) human tau is hy ...... neuronal cortical cell model.
@en
P2093
Gail V W Johnson
Pavan K Krishnamurthy
P2860
P304
P356
10.1074/JBC.M311203200
P407
P577
2003-12-02T00:00:00Z