The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa
about
MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability.Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3.Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets.Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation.Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.
P2860
The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa
description
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name
The heptapeptide LSARLAF media ...... ently of glycoprotein IIb-IIIa
@en
type
label
The heptapeptide LSARLAF media ...... ently of glycoprotein IIb-IIIa
@en
prefLabel
The heptapeptide LSARLAF media ...... ently of glycoprotein IIb-IIIa
@en
P2093
P2860
P356
P1433
P1476
The heptapeptide LSARLAF media ...... ently of glycoprotein IIb-IIIa
@en
P2093
Andrew C Pearce
Jon Frampton
Peter Wonerow
Stuart J Marshall
T Kent Gartner
P2860
P304
P356
10.1042/BJ20031298
P407
P577
2004-02-01T00:00:00Z