Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.
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The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase CCurcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitorGastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylationPhosphorylation of a UDP-glucuronosyltransferase regulates substrate specificityTwo unrelated patients with rare Crigler-Najjar syndrome type I: two novel mutations and a patient with loss of heterozygosity of UGT1A1 gene.Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924Therapeutic promises of 2-methoxyestradiol and its drug disposition challengesResveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.Microsomal quercetin glucuronidation in rat small intestine depends on age and segment.Targeted inhibition of glucuronidation markedly improves drug efficacy in mice - a model.Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene.Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytesEffect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteersIntestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics.Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence.Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention.Natural antioxidants in Alzheimer's disease.Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphismDisparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas.Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases.Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancerStructure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases.Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs.β-Glucosidase activities of lactic acid bacteria: mechanisms, impact on fermented food and human health.Transcriptional Profile for Detoxification Enzymes AeaGGT1 and AaeGGT2 From Aedes aegypti (Diptera: Culicidae) in Response to Larvicides.Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships.Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids.Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repairInfluence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.
P2860
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P2860
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Differential and special prope ...... al to control chemical uptake.
@en
type
label
Differential and special prope ...... al to control chemical uptake.
@en
prefLabel
Differential and special prope ...... al to control chemical uptake.
@en
P2093
P2860
P356
P1476
Differential and special prope ...... al to control chemical uptake.
@en
P2093
Ida S Owens
Jeong W Cho
Labanyamoy Kole
Marco Ciotti
Myung S Hwang
Nikhil K Basu
Partha S Mitra
P2860
P304
P356
10.1074/JBC.M306439200
P407
P577
2003-10-13T00:00:00Z