Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.
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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumptionToward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locusAnalysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populationsRegulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node.CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2.Caffeine, selected metabolic gene variants, and risk for neural tube defects.Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.Identification of a novel splice-site mutation in the CYP1A2 geneEffects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients.Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAMCYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessmentThe role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements clusterVariation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms.PhRMA white paper on ADME pharmacogenomics.Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2.Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.Hormonal regulation of CYP1A expression.In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Pharmacogenetics of olanzapine metabolism.Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date.Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia.Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.CYP1A1m1 and CYP2C9*2 and *3 polymorphism and risk to develop ARV-associated hepatotoxicity and its severity.The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice.Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.Role of beta-catenin in the adult liver.Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes.CYP gene family variants as potential protective factors in drug addiction in Han Chinese.Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS
P2860
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P2860
Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Organization of the CYP1A clus ...... lications for gene regulation.
@ast
Organization of the CYP1A clus ...... lications for gene regulation.
@en
type
label
Organization of the CYP1A clus ...... lications for gene regulation.
@ast
Organization of the CYP1A clus ...... lications for gene regulation.
@en
prefLabel
Organization of the CYP1A clus ...... lications for gene regulation.
@ast
Organization of the CYP1A clus ...... lications for gene regulation.
@en
P2093
P1476
Organization of the CYP1A clus ...... lications for gene regulation.
@en
P2093
Corchero J
Gonzalez FJ
Pimprale S
P356
10.1097/00008571-200102000-00001
P577
2001-02-01T00:00:00Z