Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.
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A quarter century of granzymesThe major human and mouse granzymes are structurally and functionally divergentCytotoxic proteins and therapeutic targets in severe cutaneous adverse reactionsA natural genetic variant of granzyme B confers lethality to a common viral infectionCytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosisDiscordant regulation of granzyme H and granzyme B expression in human lymphocytes.Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.Perforin-mediated target-cell death and immune homeostasis.Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with a-fucosylated anti-CD19 humanized antibodiesApoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment.Granzymes and perforin in solid organ transplant rejection.Natural killer cells in patients with severe chronic fatigue syndrome.Granzyme B-induced mitochondrial ROS are required for apoptosisAltered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascadeLive cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cellsApoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.Protease signalling in cell death: caspases versus cysteine cathepsins.Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8(+) T cells and dendritic cells.Mechanisms of granule-dependent killing.Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposureA proteomic approach for the discovery of protease substrates.Bid: a Bax-like BH3 protein.Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.Responses of A549 human lung epithelial cells to cristobalite and α-quartz exposures assessed by toxicoproteomics and gene expression analysis.Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing.Hop cleavage and function in granzyme B-induced apoptosis.Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells.Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice.Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.Targeting and amplification of immune killing of tumor cells by pro-Smac.Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathwayThe granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.
P2860
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P2860
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Caspase activation by granzyme ...... optotic mitochondrial factors.
@en
type
label
Caspase activation by granzyme ...... optotic mitochondrial factors.
@en
prefLabel
Caspase activation by granzyme ...... optotic mitochondrial factors.
@en
P2093
P1433
P1476
Caspase activation by granzyme ...... poptotic mitochondrial factors
@en
P2093
Michael Cancilla
Michelle E Wowk
Vivien R Sutton
P304
P356
10.1016/S1074-7613(03)00050-5
P407
P577
2003-03-01T00:00:00Z