Specific killing of Rb mutant cancer cells by inactivating TSC2.
about
The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stressDrosophila as a Potential Model for Ocular TumorsTwists in views on RB functions in cellular signaling, metabolism and stem cellsRB1: a prototype tumor suppressor and an enigmaThe multiple connections between pRB and cell metabolismRetinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventionsDrugging the addict: non-oncogene addiction as a target for cancer therapyProteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylationAutophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamideTumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.G1 arrest and differentiation can occur independently of Rb family function.β-Catenin is required for the tumorigenic behavior of triple-negative breast cancer cells.Targeting Rb inactivation in cancers by synthetic lethality.Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.Regulation of cell transformation by Rb-controlled redox homeostasis.RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eyeRedox signaling at invasive microdomains in cancer cells.Recent progress in targeting cancer.Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle CellsActivated E2F activity induces cell death in papillary thyroid carcinoma K1 cells with enhanced Wnt signalingRapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumorsESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signalingRoles for the Histone Modifying and Exchange Complex NuA4 in Cell Cycle Progression in Drosophila melanogaster.Loss of TSC2 confers resistance to ceramide and nutrient deprivation.Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa.Oxidative stress and therapeutic opportunities: focus on the Ewing's sarcoma family of tumors.Conserved RB functions in development and tumor suppression.Effect of atmospheric gas plasmas on cancer cell signaling.Antitumor mechanisms when pRb and p53 are genetically inactivated.Capicua regulates proliferation and survival of RB-deficient cells in Drosophila.RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy.Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell deathThe intersection of RB tumor suppressor function, stem cells, metabolism and inflammation.Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2.Mutation of the retinoblastoma tumor suppressor gene sensitizes cancers to mitotic inhibitor induced cell death.Targeting Rb mutant cancers by inactivating TSC2.Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage.Cancer metabolism: feeding a worm to starve a tumor.An Rb family-independent E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice.
P2860
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P2860
Specific killing of Rb mutant cancer cells by inactivating TSC2.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Specific killing of Rb mutant cancer cells by inactivating TSC2.
@en
type
label
Specific killing of Rb mutant cancer cells by inactivating TSC2.
@en
prefLabel
Specific killing of Rb mutant cancer cells by inactivating TSC2.
@en
P2093
P2860
P1433
P1476
Specific killing of Rb mutant cancer cells by inactivating TSC2.
@en
P2093
Binghui Li
Charles H Du
Gabriel M Gordon
P2860
P304
P356
10.1016/J.CCR.2010.03.019
P577
2010-05-01T00:00:00Z