A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade.
about
The protease inhibitor bikunin, a novel anti-metastatic agentOxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cellsDrug development against metastasis-related genes and their pathways: A rationale for cancer therapyOptimizing molecular-targeted therapies in ovarian cancer: the renewed surge of interest in ovarian cancer biomarkers and cell signaling pathways.Cloning and Characterization of Two Potent Kunitz Type Protease Inhibitors from Echinococcus granulosusEndogenous anti-inflammatory substances, inter-alpha-inhibitor and bikunin.Ulinastatin reduces cancer recurrence after resection of hepatic metastases from colon cancer by inhibiting MMP-9 activation via the antifibrinolytic pathway.Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders.The antifibrotic effect of a serine protease inhibitor in the kidney.Epigenetic inactivation and tumor suppressor activity of HAI-2/SPINT2 in gastric cancer.A simple procedure for isolating microgram quantities of biologically active bikunin from human urine.Suppression of urokinase expression and invasion by a soybean Kunitz trypsin inhibitor are mediated through inhibition of Src-dependent signaling pathways.A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings.Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells.Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells.Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression.Protective role of urinary trypsin inhibitor in lung expression of proinflammatory cytokines accompanied by lethal liver injury in mice.Identification of differentially expressed genes in psoriasis using expression profiling approaches.Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells.The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.Subclassification and Detection of New Markers for the Discrimination of Primary Liver Tumors by Gene Expression Analysis Using Oligonucleotide Arrays.
P2860
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P2860
A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
A Kunitz-type protease inhibit ...... ctor-beta 1 signaling cascade.
@en
type
label
A Kunitz-type protease inhibit ...... ctor-beta 1 signaling cascade.
@en
prefLabel
A Kunitz-type protease inhibit ...... ctor-beta 1 signaling cascade.
@en
P2093
P2860
P356
P1476
A Kunitz-type protease inhibit ...... ctor-beta 1 signaling cascade.
@en
P2093
Hiroshi Kobayashi
Mika Suzuki
Naohiro Kanayama
Toshihiko Terao
Yoshiko Tanaka
P2860
P304
P356
10.1074/JBC.M210407200
P407
P577
2002-12-20T00:00:00Z