Signaling by the cytokine receptor superfamily: JAKs and STATs.
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Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.Stat1 associates with c-kit and is activated in response to stem cell factorMouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathwayA novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptorsA proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa BTec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor bindingFocal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic diseaseThe biology and mechanism of action of suppressor of cytokine signaling 3The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology regionCrystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid LigandChemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of actionThe human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cellsA catalytically active Jak2 is required for the angiotensin II-dependent activation of FynInterleukin-6, CD45 and the src-kinases in myeloma cell proliferationDominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transductionRole of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinasesA kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cellsInterleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesPhosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptorThe tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD miceMolecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophagesPhosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinaseShp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathwayDifferential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerizationTemporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagementRegulation of STAT1 nuclear export by Jak1Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells.Cloning of the murine beta5 integrin subunit promoter. Identification of a novel sequence mediating granulocyte-macrophage colony-stimulating factor-dependent repression of beta5 integrin gene transcription.CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.Differential baseline and response profile to IFN-gamma gene transduction of IL-6/IL-6 receptor-alpha secretion discriminate primary tumors versus bone marrow metastases of nasopharyngeal carcinomas in culture.Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation.
P2860
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P2860
Signaling by the cytokine receptor superfamily: JAKs and STATs.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Signaling by the cytokine receptor superfamily: JAKs and STATs.
@en
type
label
Signaling by the cytokine receptor superfamily: JAKs and STATs.
@en
prefLabel
Signaling by the cytokine receptor superfamily: JAKs and STATs.
@en
P2093
P1476
Signaling by the cytokine receptor superfamily: JAKs and STATs
@en
P2093
B A Witthuhn
K Yamamoto
O Silvennoinen
W E Thierfelder
P304
P356
10.1016/0968-0004(94)90026-4
P577
1994-05-01T00:00:00Z