Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction - Wikidata - wikimedia - TriplyDB

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

http://www.wikidata.org/entity/Q28278147

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Interleukin-6 induces hepcidin expression through STAT3 Crif1 is a novel transcriptional coactivator of STAT3 Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation Principles of interleukin (IL)-6-type cytokine signalling and its regulation Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Nucleic acid-based approaches to STAT inhibition Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity.Stat3 activation is required for the growth of U87 cell-derived tumours in mice Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCβII abundance Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.Rac1 mediates STAT3 activation by autocrine IL-6 Tetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells.Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein.The Molecular Signatures Database (MSigDB) hallmark gene set collection Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling.Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation.STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models STAT3 is necessary for proliferation and survival in colon cancer-initiating cells.PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors.Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages.Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis.Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation.Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB In vitro activation of Stat3 by epidermal growth factor receptor kinase Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.

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Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

http://www.wikidata.org/entity/Q28278147

description

1996 nî lūn-bûn

@nan

1996 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի մարտին հրատարակված գիտական հոդված

@hy

1996年の論文

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1996年論文

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1996年論文

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1996年論文

@zh-hk

1996年論文

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1996年論文

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1996年论文

@wuu

name

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@ast

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@en

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@nl

type

label

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@ast

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@en

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@nl

prefLabel

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@ast

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@en

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@nl

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JBC.271.11.5961

P1433

Journal of Biological Chemistry

P1476

Dominant negative stat3 mutant ...... d Jak-STAT signal transduction

@en

P2093

A Kaptein

http://www.w3.org/2001/XMLSchema#string

M Saunders

http://www.w3.org/2001/XMLSchema#string

V Paillard

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Signal transduction by receptors with tyrosine kinase activity

SH2 domains recognize specific phosphopeptide sequences

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

Cytokine signal transduction

A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

P304

5961-4

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scholarly article

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221683

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10.1074/JBC.271.11.5961

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P433

11

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P478

271

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8626374

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