The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.
about
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsSevere combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationRegulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteinsPyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathwaySevere combined immunodeficiencies (SCID)Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteinsHuman and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene inductionLoss of hippocampal CA3 pyramidal neurons in mice lacking STAM1.A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection.Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7Cytokines and immunodeficiency diseases.CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSPTargeting the Jak/STAT pathway for immunosuppression.An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selectionThe common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasisSerum soluble interleukin 2 receptor alpha in human cancer of adults and children: a review.Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.Interleukin 7 independent development of human B cells.Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.Severe combined immunodeficiences: new and old scenarios.Targeting kinases for the treatment of inflammatory diseases.Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia.An interleukin-2 receptor gamma chain mutation with normal thymus morphology.Cytokine receptor genes: structure, chromosomal location, and involvement in human disease.Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations.Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast.The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts.Impact of knockout mice in toxicology.Deletion of the acidic-rich domain of the IL-2Rbeta chain increases receptor-associated PI3K activity.Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients.STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain
P2860
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P2860
The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The molecular basis of X-linke ...... a common gamma chain, gamma c.
@en
type
label
The molecular basis of X-linke ...... a common gamma chain, gamma c.
@en
prefLabel
The molecular basis of X-linke ...... a common gamma chain, gamma c.
@en
P2093
P2860
P1476
The molecular basis of X-linke ...... a common gamma chain, gamma c.
@en
P2093
Leonard WJ
McBride OW
Russell SM
P2860
P356
10.1111/J.1600-065X.1994.TB00847.X
P577
1994-04-01T00:00:00Z