Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site.
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Na+ binding to meizothrombin desF1Mutant N143P Reveals How Na+ Activates ThrombinRigidification of the autolysis loop enhances Na+ binding to thrombinNew insights into the spatiotemporal localization of prothrombinase in vivo.Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrateFunctional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitroMolecular basis of the clotting defect in a bleeding patient missing the Asp-185 codon in the factor X gene.Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.Redesigning allosteric activation in an enzyme.Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonistLyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity.Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cellsA bipartite autoinhibitory region within the B-domain suppresses function in factor VDeterminants of specificity in coagulation proteases.Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/XaPhosphatidylserine-induced factor Xa dimerization and binding to factor Va are competing processes in solution.Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.Role of Na+ and K+ in enzyme function.Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complexThrombin.Exosites in the substrate specificity of blood coagulation reactions.Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptidesVenom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations.Mutagenesis studies toward understanding allostery in thrombin.Structural biology of factor VIIa/tissue factor initiated coagulationThe conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly.The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex.Removal of B-domain sequences from factor V rather than specific proteolysis underlies the mechanism by which cofactor function is realized.Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors.Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI.High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.Molecular dissection of Na+ binding to thrombin.
P2860
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P2860
Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Prothrombinase assembly and S1 ...... on at the sodium-binding site.
@en
type
label
Prothrombinase assembly and S1 ...... on at the sodium-binding site.
@en
prefLabel
Prothrombinase assembly and S1 ...... on at the sodium-binding site.
@en
P2860
P356
P1476
Prothrombinase assembly and S1 ...... on at the sodium-binding site.
@en
P2093
Rodney M Camire
P2860
P304
37863-37870
P356
10.1074/JBC.M203692200
P407
P577
2002-07-30T00:00:00Z