Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells.
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Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cellsThe hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cellsHyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasionThe biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectivesConcise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic TargetCD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating CellsInteraction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invaGalectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cellsRegulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastomaTumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives.CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury.Natural and synthetic progestins enrich cancer stem cell-like cells in hormone-responsive human breast cancer cell populations in vitro.NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway.Expression of ALDH1 and TGFβ2 in benign and malignant breast tumors and their prognostic implicationsThree-dimensional in vitro tumor models for cancer research and drug evaluation.Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan.Involvement of hyaluronan in regulation of fibroblast phenotype.In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver.Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity.Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease.Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes.Hyaluronan-CD44 interactions as potential targets for cancer therapy.The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.Hyaluronan regulation of vascular integrityMechanism of MTA1 protein overexpression-linked invasion: MTA1 regulation of hyaluronan-mediated motility receptor (HMMR) expression and function.Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex NetworksMultilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repairHyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions.Renal Fibrosis mRNA Classifier: Validation in Experimental Lithium-Induced Interstitial Fibrosis in the Rat Kidney.Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis.Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.Intracellular domain fragment of CD44 alters CD44 function in chondrocytes.Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironmentTransforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb
P2860
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P2860
Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Hyaluronan promotes signaling ...... metastatic breast tumor cells.
@en
type
label
Hyaluronan promotes signaling ...... metastatic breast tumor cells.
@en
prefLabel
Hyaluronan promotes signaling ...... metastatic breast tumor cells.
@en
P2093
P2860
P356
P1476
Hyaluronan promotes signaling ...... metastatic breast tumor cells.
@en
P2093
Hongbo Zhu
Lilly Y W Bourguignon
Patrick A Singleton
P2860
P304
39703-39712
P356
10.1074/JBC.M204320200
P407
P577
2002-07-26T00:00:00Z