Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone. - Wikidata - wikimedia - TriplyDB

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

http://www.wikidata.org/entity/Q40737006

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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.Localization and function of cytosolic phospholipase A2alpha at the Golgi.A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism Group IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation.Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics.Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activity Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes.Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins.Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.Orexin/hypocretin receptor signalling cascades.Roles of ERK and cPLA2 in the angiotensin II-mediated biphasic regulation of Na+-HCO3(-) transport.Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells.Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS.Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages.Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils.Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A2.Flow cytometric analysis of ca-induced membrane permeability transition of isolated rat liver mitochondria.Involvement of calcium-independent phospholipase A2 in hydrogen peroxide-induced accumulation of free fatty acids in human U937 cells.In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors.Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.Calcium-independent phospholipase A2-mediated formation of 1,2-diarachidonoyl-glycerophosphoinositol in monocytes.Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells.Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity.Selectivity of cytosolic phospholipase A2 type IV toward arachidonyl phospholipids.pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics.

P2860

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P2860

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

http://www.wikidata.org/entity/Q40737006

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

@en

type

label

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

@en

prefLabel

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

@en

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Biochemical Journal

P1476

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

@en

P2093

Kaoru Seno

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Katsutoshi Yamada

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Masahiko Ueno

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Shozo Nakamoto

http://www.w3.org/2001/XMLSchema#string

Takashi Ono

http://www.w3.org/2001/XMLSchema#string

Takayuki Okuno

http://www.w3.org/2001/XMLSchema#string

Yukiko Chikazawa

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s

Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism

Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.

Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

Structure and mechanism of human cytosolic phospholipase A(2).

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Pt 3

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363

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2002-05-01T00:00:00Z

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247449682

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11964173

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