Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis.
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Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoffViral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral responseThe 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functionalPKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in NeuronsDifferential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived AlphavirusesAlpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent MechanismStructural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine VirulenceDC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived VirusesModulation of type I IFN induction by a virulence determinant within the alphavirus nsP1 proteinIdentification and characterization of interferon-induced proteins that inhibit alphavirus replicationAntiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA virusesSARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism.Role of PKR and Type I IFNs in viral control during primary and secondary infection.Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cellsGamma interferon-dependent, noncytolytic clearance of sindbis virus infection from neurons in vitroEarly alpha/beta interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88.Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neuronsInduction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.Apoptosis is essential for the increased efficacy of alphaviral replicase-based DNA vaccines.Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function.Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses.Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate.Myd88-dependent toll-like receptor 7 signaling mediates protection from severe Ross River virus-induced disease in miceInfected dendritic cells are sufficient to mediate the adjuvant activity generated by Venezuelan equine encephalitis virus replicon particlesEastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis.Noncytolytic clearance of sindbis virus infection from neurons by gamma interferon is dependent on Jak/STAT signaling.Type I and type II interferons inhibit the translation of murine norovirus proteins.Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses.Acute infection with venezuelan equine encephalitis virus replicon particles catalyzes a systemic antiviral state and protects from lethal virus challengeCytokine determinants of viral tropism.Interferon-stimulated genes: roles in viral pathogenesis.Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease.Protection of guinea pigs by vaccination with a recombinant swinepox virus co-expressing HA1 genes of swine H1N1 and H3N2 influenza viruses.Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency.Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses.PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection.Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System.
P2860
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P2860
Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Effects of PKR/RNase L-depende ...... replication and pathogenesis.
@en
type
label
Effects of PKR/RNase L-depende ...... replication and pathogenesis.
@en
prefLabel
Effects of PKR/RNase L-depende ...... replication and pathogenesis.
@en
P2093
P1433
P1476
Effects of PKR/RNase L-depende ...... replication and pathogenesis.
@en
P2093
Kate D Ryman
Laura J White
Robert E Johnston
William B Klimstra
P356
10.1089/088282402317340233
P577
2002-01-01T00:00:00Z