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Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug designHighly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of ActionMolecular Determinants of GS-9620-Dependent TLR7 ActivationTenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistatRole of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.Novel acyclic nucleotide analogues GS-343074 and GS-424044 demonstrate antiproliferative and pro-apoptotic activity in canine neoplastic cell lines.Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides.Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors.Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides.Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon.Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Gabriel Birkus
@ast
Gabriel Birkus
@en
Gabriel Birkus
@es
Gabriel Birkus
@nl
Gabriel Birkus
@sl
type
label
Gabriel Birkus
@ast
Gabriel Birkus
@en
Gabriel Birkus
@es
Gabriel Birkus
@nl
Gabriel Birkus
@sl
prefLabel
Gabriel Birkus
@ast
Gabriel Birkus
@en
Gabriel Birkus
@es
Gabriel Birkus
@nl
Gabriel Birkus
@sl
P1053
G-7765-2016
P106
P21
P31
P3829
P496
0000-0002-5537-9447