Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
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Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977Synthesis of nucleoside phosphate and phosphonate prodrugsProdrugs of phosphonates and phosphates: crossing the membrane barrierNew Antiretroviral Treatment for HIVA cutting-edge view on the current state of antiviral drug development.Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917.In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate.Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy.Anti-HIV Nucleoside Phosphonate GS-9148 and Its Prodrug GS-9131: Scale Up of a 2'-F Modified Cyclic Nucleoside Phosphonate and Synthesis of Selected Amidate Prodrugs.Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide for the treatment of HIV in adults.ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolitesThe role of tenofovir alafenamide in future HIV management.Rilpivirine, emtricitabine and tenofovir alafenamide: single-tablet combination for the treatment of HIV-1 infection in selected patients.Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection.Tenofovir Alafenamide.Emtricitabine + tenofovir alafenamide for the treatment of HIV.Tenofovir alafenamide, emtricitabine, elvitegravir, and cobicistat combination therapy for the treatment of HIV.Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.Tenofovir alafenamide for the treatment of chronic hepatitis B virus infection.Tenofovir Alafenamide: A Review in Chronic Hepatitis B.Long acting systemic HIV pre-exposure prophylaxis: an examination of the field.Effects of a Nutritional Protein-Rich Drink on the Pharmacokinetics of Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Alafenamide, and Tenofovir Compared With a Standard Meal in Healthy Japanese Male Subjects.Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapyThe ProTides Boom.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine.Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial DepolarizationHormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells.Applying the prodrug strategy to α-phosphonocarboxylate inhibitors of Rab GGTase--synthesis and stability studies.
P2860
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P2860
Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.
@en
type
label
Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.
@en
prefLabel
Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.
@en
P2093
P2860
P356
P1476
Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.
@en
P2093
Craig Gibbs
Holly MacArthur
Martin McDermott
Nilima Kutty
Swami Swaminathan
Tomas Cihlar
William Lee
Xiaohong Liu
P2860
P304
P356
10.1128/AAC.00968-06
P407
P577
2006-12-04T00:00:00Z