Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.
about
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington diseaseAdvancing pharmacotherapy for treating Huntington's disease: a review of the existing literature.Pridopidine for the treatment of Huntington's disease.Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases.Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503.Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease.Pridopidine activates neuroprotective pathways impaired in Huntington Disease.Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.Safety and Exploratory Efficacy at 36 Months in Open-HART, an Open-Label Extension Study of Pridopidine in Huntington's Disease.Pridopidine Reverses Phencyclidine-Induced Memory Impairment.Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy
P2860
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P2860
Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Pridopidine selectively occupi ...... at behaviorally active doses.
@en
type
label
Pridopidine selectively occupi ...... at behaviorally active doses.
@en
prefLabel
Pridopidine selectively occupi ...... at behaviorally active doses.
@en
P2093
P2860
P1433
P1476
Pridopidine selectively occupi ...... at behaviorally active doses.
@en
P2093
Aren van Waarde
Chantal Kwizera
Jurgen W A Sijbesma
Nisha K Ramakrishnan
Philip H Elsinga
Rudi A J O Dierckx
P2860
P2888
P304
P356
10.1007/S00213-015-3997-8
P577
2015-07-11T00:00:00Z
P5875
P6179
1011078065