Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses. - Wikidata - wikimedia - TriplyDB

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.

http://www.wikidata.org/entity/Q40753593

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The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease Advancing pharmacotherapy for treating Huntington's disease: a review of the existing literature.Pridopidine for the treatment of Huntington's disease.Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases.Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503.Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease.Pridopidine activates neuroprotective pathways impaired in Huntington Disease.Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.Safety and Exploratory Efficacy at 36 Months in Open-HART, an Open-Label Extension Study of Pridopidine in Huntington's Disease.Pridopidine Reverses Phencyclidine-Induced Memory Impairment.Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy

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Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.

http://www.wikidata.org/entity/Q40753593

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Pridopidine selectively occupi ...... at behaviorally active doses.

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type

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Pridopidine selectively occupi ...... at behaviorally active doses.

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Pridopidine selectively occupi ...... at behaviorally active doses.

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Psychopharmacology

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Pridopidine selectively occupi ...... at behaviorally active doses.

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Aren van Waarde

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Bram Maas

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Chantal Kwizera

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Jurgen W A Sijbesma

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Nisha K Ramakrishnan

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Philip H Elsinga

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Rudi A J O Dierckx

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P2860

The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers

Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain

Sigma receptors: biology and therapeutic potential

Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review.

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

In vivo pharmacology of the dopaminergic stabilizer pridopidine.

Analysis of the actions of the novel dopamine receptor-directed compounds (S)-OSU6162 and ACR16 at the D2 dopamine receptor.

Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial.

The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins.

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s00213-015-3997-8

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Daniel Marcellino

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2015-07-11T00:00:00Z

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