Hetero-oligomerization does not compromise 'gain of function' of tumor-derived p53 mutants.
about
Mutant p53 gain-of-function in cancer.Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistanceMutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.Mutant p53 promotes ovarian cancer cell adhesion to mesothelial cells via integrin β4 and Akt signalsTranscription regulation by mutant p53.Wild-type p53 and p73 negatively regulate expression of proliferation related genes.A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels.p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity.Tumor-derived p53 mutants induce NF-kappaB2 gene expression.Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.Non-canonical p53 signaling to promote invasion.Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism
P2860
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P2860
Hetero-oligomerization does not compromise 'gain of function' of tumor-derived p53 mutants.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Hetero-oligomerization does no ...... of tumor-derived p53 mutants.
@en
type
label
Hetero-oligomerization does no ...... of tumor-derived p53 mutants.
@en
prefLabel
Hetero-oligomerization does no ...... of tumor-derived p53 mutants.
@en
P2093
P2860
P356
P1433
P1476
Hetero-oligomerization does no ...... of tumor-derived p53 mutants.
@en
P2093
Abhay Sankar Chakraborti
Debabrita Deb
Jane Keiger
Katherine E Roth
Mariano Scian
Sumitra Deb
Swati Palit Deb
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205035
P407
P577
2002-01-01T00:00:00Z
P5875
P6179
1051881086