Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
about
Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhereIntegrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding propertiesMechanical regulation of T-cell functionsStructures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bondsObserving force-regulated conformational changes and ligand dissociation from a single integrin on cells.Display technologies: application for the discovery of drug and gene delivery agents.An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.Beta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering.Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes.Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 bindingSelective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.Molecular proximity of Kv1.3 voltage-gated potassium channels and beta(1)-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers.Leukotoxin (Leukothera®) targets active leukocyte function antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway.Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation.Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLsA mechanism for antibody-mediated outside-in activation of LFA-1.Characterization of binding properties of ICAM-1 peptides to LFA-1: inhibitors of T-cell adhesion.2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1.LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells.Co-culture of hematopoietic stem cells with mesenchymal stem cells increases VCAM-1-dependent migration of primitive hematopoietic stem cells.
P2860
Q24537227-A12C6F72-6182-4C47-AEF6-A7773BACAD22Q24538851-8E454840-C262-482C-8521-8304C3BAF51AQ27016079-9789A18F-1BDD-44F5-B277-C5234D0CF438Q27640304-4331C2B9-D7CC-4F04-860B-92EE140F9341Q30497295-6B56DD67-EA7D-4B04-8393-698C5D8F505EQ30527786-F81E6184-F911-49BF-BF9E-5514745B9FCBQ33264491-B6EE9AFA-9BB3-46B9-9900-0E696A2E7AA1Q33927511-96B750F6-C25C-4B95-8EFB-4CD2A134A097Q34186139-212F8A40-4586-46B3-BCED-690522C5B4AAQ35001301-C2419AF4-EF7B-4CED-8ACB-A4A90AF16FA3Q35137817-47DEC602-8EB7-4508-97E5-83DBA43AACF3Q35676793-E3B474ED-7420-4269-B8D1-5FDCE684460CQ36558200-F4E0D565-9DD5-4DD8-9F2C-92C33F41D344Q39370760-F67FAFF9-882A-4A35-A2C7-7C4530422506Q39559416-4021D626-E651-474F-95D0-47996A060FAAQ39847298-1665ACDB-8AE1-4EF6-A90E-29F143D7F290Q40024433-F981259F-A8A7-4867-9D32-DFF1B4601F99Q40241335-FA2E063B-941D-4B35-AE69-B3BEC87CF190Q41892335-6F908869-C48B-4E3F-9B74-6473BEA0B050Q43136846-CF484AEF-5862-4B2B-A535-D61C6538C803Q53202186-612A7EE1-2DD2-424D-9315-0A25A15FEBE3
P2860
Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Activation-induced conformatio ...... function-associated antigen 1.
@en
type
label
Activation-induced conformatio ...... function-associated antigen 1.
@en
prefLabel
Activation-induced conformatio ...... function-associated antigen 1.
@en
P2093
P2860
P356
P1476
Activation-induced conformatio ...... function-associated antigen 1
@en
P2093
Motomu Shimaoka
Timothy A Springer
P2860
P304
10638-10641
P356
10.1074/JBC.M112417200
P407
P577
2002-01-15T00:00:00Z