Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines.
about
The enigmatic X gene of hepatitis B virusProteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replicationPolo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidyTumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by hepatitis B virus X protein in malignant hepatocytesAltered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x proteinHepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis.Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway.Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cellsElevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18.Aggregate formation of hepatitis B virus X protein affects cell cycle and apoptosis.Expression of hepatitis B virus X protein in transgenic mice.Transcriptome-Wide Analysis of Hepatitis B Virus-Mediated Changes to Normal Hepatocyte Gene Expression.Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma CellsHepatitis B virus X protein mediated suppression of miRNA-122 expression enhances hepatoblastoma cell proliferation through cyclin G1-p53 axisMolecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections.Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression.The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.Hepatitis B Virus X and Regulation of Viral Gene Expression.Homeodomain transcription factor Phox2a, via cyclic AMP-mediated activation, induces p27Kip1 transcription, coordinating neural progenitor cell cycle exit and differentiation.The mitogenic function of hepatitis B virus X protein resides within amino acids 51 to 140 and is modulated by N- and C-terminal regulatory regions.The hepatitis B virus HBx protein modulates cell cycle regulatory proteins in cultured primary human hepatocytes.Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytesHepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1.Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication.Possible mechanism for hepatitis B virus X gene to induce apoptosis of hepatocytes.Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expressionThe vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication.Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis.High-level activation of cyclic AMP signaling attenuates bone morphogenetic protein 2-induced sympathoadrenal lineage development and promotes melanogenesis in neural crest cultures.Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes.Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein.The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication.Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaB and the mitochondrial permeability transition pore.The cAMP pathway in combination with BMP2 regulates Phox2a transcription via cAMP response element binding sites.HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint.
P2860
Q24561887-5A10AB8F-90B0-443C-9546-4339D5FB6E5FQ33867835-2DF5ED28-EEF6-4466-818E-D849D716DA7DQ34144573-B9A80E27-16C4-4779-BB6B-928AEDD84520Q34308946-B6BC6690-7E76-4B1A-B1E9-868A735D75BAQ34355312-88AB91A9-6971-45D0-A90E-09D38B89490CQ34765478-30BB2ACE-8E70-436E-978A-2C3D80ECA7B9Q35067194-4954C6F4-032D-470E-911F-5A5808ED56EEQ35104748-2A5E4A24-6293-4620-BFA7-AE85174E2CF6Q35292450-3B69DFC8-208B-486C-B0D9-87A949ACD39FQ36122238-00C68AC3-D890-4CD9-8B87-DF9FF1D53890Q36190691-51CD6F7C-0B92-4761-B46D-C2438932FF9DQ36506290-57903E60-D375-44A4-8643-0845847FA7F7Q36593582-4585FA0F-F1FD-4086-8D31-46EF72C451E2Q36956039-05A8B846-2E04-42C9-ABD5-8421101B37B2Q37172987-98249889-7615-44BC-884E-43EED49D32FEQ37295260-5357BC9E-C3DB-477D-AE14-38873F4706E0Q37457851-15BC6AF1-9663-4B96-95D0-E037F8CF97ADQ38246712-B0E4705D-A190-4EF5-B7D9-E850AEB3BD7AQ38310248-F896A31E-AA9E-481D-BBA7-1B45507CEB8AQ38690987-700FCD32-EDC6-42BE-BCCE-ABD22B9D8B4CQ39127532-FE956529-4B3A-4297-A5A5-2C14E5E87A38Q39291956-F0D5C62E-FA58-4EC2-8491-5DFD0F01C944Q39646213-24AED13A-446F-404F-A64F-4D43D4202E0AQ39684768-F58A9423-DA0A-4ED5-8F17-2A6D50092C9CQ39941606-1CF43EBE-181C-4044-B6A6-88A9363848ABQ39951895-CE01C4B3-593A-4305-9D71-202DF7EB7C26Q40293038-CFAAD79B-757A-4A85-8A62-04DDF00A3C32Q40394559-AF8CF0B9-AB6C-41AE-AF7A-7A1A5CA34B4FQ40419557-A34F1E37-DE9B-4EF1-B15D-0CFD3260A1EAQ40577848-37BAE2EC-4CB8-43A1-AF5C-24DB1E2AFFAAQ41826006-38617815-5756-4674-B5E3-D09CFB3FD034Q42181624-C8BD6683-B231-4185-AEF7-FD4D23CFB367Q42198282-AC7FCA06-74E5-4806-B869-53D439070434Q42272234-6AB07D33-313E-4F3C-90FF-E0373A1A2326Q42910063-F2604BC2-DD5B-430C-B53B-537653B59090Q43127381-19D0B640-EC15-4F2C-9494-04DF965C07BCQ46837678-C746293E-02A2-455D-B116-BA71FAD77D96Q53505460-43C824B2-4B1E-44D5-AA40-6AA3D21A385D
P2860
Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Hepatitis B virus X protein di ...... hepatocyte (AML12) cell lines.
@en
type
label
Hepatitis B virus X protein di ...... hepatocyte (AML12) cell lines.
@en
prefLabel
Hepatitis B virus X protein di ...... hepatocyte (AML12) cell lines.
@en
P2093
P2860
P356
P1476
Hepatitis B virus X protein di ...... hepatocyte (AML12) cell lines.
@en
P2093
Ronald L Hullinger
Sigeng Chen
Wen-Horng Wang
P2860
P304
P356
10.1074/JBC.M108025200
P407
P577
2001-12-26T00:00:00Z