about
Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptorsEnhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABASlow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic functionHomeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABA(A) receptors.Subunit-specific trafficking of GABA(A) receptors during status epilepticusModulation of spontaneous and GABA-evoked tonic alpha4beta3delta and alpha4beta3gamma2L GABAA receptor currents by protein kinase A.Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.Calcium-dependent block of P2X7 receptor channel function is allosteric.Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex.Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors.Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.Acute alcohol action and desensitization of ligand-gated ion channels.Mutations in GABAA receptor subunits associated with genetic epilepsies.Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study.Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.Context dependent benzodiazepine modulation of GABA(A) receptor opening frequencyThe alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics.Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site.Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor.Analysis of macroscopic ionic currents mediated by GABArho1 receptors during lanthanide modulation predicts novel states controlling channel gating.Molecular pathology of genetic epilepsies associated with GABAA receptor subunit mutations.Loop G in the GABAA receptor α1 subunit influences gating efficacy.Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA receptors
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Agonist Trapping by GABAA Receptor Channels.
@en
type
label
Agonist Trapping by GABAA Receptor Channels.
@en
prefLabel
Agonist Trapping by GABAA Receptor Channels.
@en
P1476
Agonist Trapping by GABAA Receptor Channels
@en
P2093
M T Bianchi
R L Macdonald
P304
P356
10.1523/JNEUROSCI.21-23-09083.2001
P407
P577
2001-12-01T00:00:00Z