Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.
about
Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABA(A) receptors.Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?Kinetic analysis of evoked IPSCs discloses mechanism of antagonism of synaptic GABAA receptors by picrotoxin.Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currentsImmature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity.Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABAA receptorComparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors.Chronic benzodiazepine-induced reduction in GABA(A) receptor-mediated synaptic currents in hippocampal CA1 pyramidal neurons prevented by prior nimodipine injection.Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibition.Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics.Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study.Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.Context dependent benzodiazepine modulation of GABA(A) receptor opening frequencyPhenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus.Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA receptors
P2860
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P2860
Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Microscopic kinetic determinan ...... ensitization and deactivation.
@en
Microscopic kinetic determinan ...... ensitization and deactivation.
@nl
type
label
Microscopic kinetic determinan ...... ensitization and deactivation.
@en
Microscopic kinetic determinan ...... ensitization and deactivation.
@nl
prefLabel
Microscopic kinetic determinan ...... ensitization and deactivation.
@en
Microscopic kinetic determinan ...... ensitization and deactivation.
@nl
P2093
P2860
P1476
Microscopic kinetic determinan ...... ensitization and deactivation.
@en
P2093
Emmanuel J Botzolakis
Janet L Fisher
Kevin F Haas
Matt T Bianchi
Robert L Macdonald
P2860
P304
P356
10.1113/JPHYSIOL.2007.142364
P407
P577
2007-09-20T00:00:00Z