Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.
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Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic NephropathyOxidant Mechanisms in Renal Injury and DiseaseContribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds.NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agentsDevelopment of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening.Toll-like receptor 4-mediated nuclear factor kappa B activation is essential for sensing exogenous oxidants to propagate and maintain oxidative/nitrosative cellular stress.Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma.Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule InhibitorsIntermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite FormationDenervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondriaElectrophiles in foods: the current status of isothiocyanates and their chemical biology.Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways.Selected ebselen analogs reduce mechlorethamine toxicity in vitro.Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes.Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen.Ebselen abrogates TNFalpha induced pro-inflammatory response in glioblastoma.Stroke status evoked adhesion molecule genetic alterations in astrocytes isolated from stroke-prone spontaneously hypertensive rats and the apigenin inhibition of their expressionMethylmercury-induced alterations in astrocyte functions are attenuated by ebselen.Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status.Ebselen Preserves Tissue-Engineered Cell Sheets and their Stem Cells in Hypothermic Conditions.3-(2,6-dimethylphenyl)-2-selenoxo-1,3-thiazolidin-4-one suppresses hydrogen peroxide-induced cytotoxicity on PC12 cells via activation of MAPK.2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production.Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.Glutathione peroxidase protein expression and activity in human islets isolated for transplantation.Preparation of 2,3-dihydroselenolo[2,3-b]pyridines and related compounds by free-radical means.BHT blocks NF-kappaB activation and ethanol-induced brain damage.Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission.Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs.Inhibition of ERK oscillations by ionizing radiation and reactive oxygen species.Quantum Mechanical Approaches to Selenium Biochemistry
P2860
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P2860
Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Ebselen, a glutathione peroxid ...... ion-associated carcinogenesis.
@en
type
label
Ebselen, a glutathione peroxid ...... ion-associated carcinogenesis.
@en
prefLabel
Ebselen, a glutathione peroxid ...... ion-associated carcinogenesis.
@en
P2093
P2860
P356
P1476
Ebselen, a glutathione peroxid ...... ion-associated carcinogenesis.
@en
P2093
Etsuo Niki
Hajime Ohigashi
Koji Torikai
Koji Uchida
Noriko Noguchi
Takeshi Kumagai
Toshihiko Osawa
Yoshimasa Nakamura
P2860
P304
P356
10.1074/JBC.M109641200
P407
P577
2001-11-19T00:00:00Z