WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
about
Development and regulation of chloride homeostasis in the central nervous systemGABAA receptor subtype involvement in addictive behaviour.A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.WNK Kinases in Development and Disease.With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransportersInhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2Contribution of Resting Conductance, GABAA-Receptor Mediated Miniature Synaptic Currents and Neurosteroid to Chloride Homeostasis in Central Neurons.Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibitionGABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase.Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity.The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures.The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition.Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels.The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice
P2860
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P2860
WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
description
2015 nî lūn-bûn
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2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
WNK1-regulated inhibitory phos ...... n of GABA in immature neurons.
@en
type
label
WNK1-regulated inhibitory phos ...... n of GABA in immature neurons.
@en
prefLabel
WNK1-regulated inhibitory phos ...... n of GABA in immature neurons.
@en
P2093
P2860
P1433
P1476
WNK1-regulated inhibitory phos ...... on of GABA in immature neurons
@en
P2093
Arjun R Khanna
Emmanuelle Buhler
Fabienne Schaller
JingJing Duan
Jinwei Zhang
Kevan M Shokat
Kristopher T Kahle
Lucie I Pisella
Paul N Bishop
Perrine Friedel
P2860
P356
10.1126/SCISIGNAL.AAA0354
P577
2015-06-30T00:00:00Z