The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters
about
The search for novel analgesics: targets and mechanismsK-Cl cotransporters, cell volume homeostasis, and neurological diseaseCurrent view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulationMolecular and evolutionary insights into the structural organization of cation chloride cotransportersSphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increaseActions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.Cation-chloride cotransporters in neuronal development, plasticity and diseaseKCC2 activity is critical in limiting the onset and severity of status epilepticus.Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic painCritical role of the SPAK protein kinase CCT domain in controlling blood pressureInduction of Suicidal Erythrocyte Death by CantharidinRegulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophreniaA noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyHypertension: the missing WNKs.The expression, regulation, and function of Kir4.1 (Kcnj10) in the mammalian kidney.Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brainCompromising KCC2 transporter activity enhances the development of continuous seizure activity.The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells.Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.SPAK mediates KCC3-enhanced cervical cancer tumorigenesis.WNK Kinases in Development and Disease.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransportersInhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl- Channel.Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis.WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell LinesGABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase.K+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective.N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.WNK Signaling Inhibitors as Potential Antihypertensive Drugs.The signaling role for chloride in the bidirectional communication between neurons and astrocytes.
P2860
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P2860
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@ast
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en-gb
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@nl
type
label
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@ast
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en-gb
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@nl
prefLabel
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@ast
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en-gb
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
The WNK-regulated SPAK/OSR1 ki ...... bit the K+-Cl- co-transporters
@en
P2093
David G Campbell
Kristopher T Kahle
Paola de Los Heros
Robert Gourlay
Thomas J Macartney
P2860
P304
P3181
P356
10.1042/BJ20131478
P407
P577
2014-03-15T00:00:00Z