Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo.
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Progresses towards safe and efficient gene therapy vectorsGene therapy for hemophiliaThe HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction.Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.Gene therapy of hepatocarcinoma: a long way from the concept to the therapeutical impact.Lentiviral gene transfer into the dorsal root ganglion of adult rats.Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infectionStrategies to insulate lentiviral vector-expressed transgenesLentiviral vector design using alternative RNA export elements.Preclinical and clinical gene therapy for haemophilia.Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection.Evading the immune response upon in vivo gene therapy with viral vectors.20-HETE mediates proliferation of renal epithelial cells in polycystic kidney diseaseTransgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis.A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells.The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis.Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell typeA minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap.Wild-type and central DNA flap defective HIV-1 lentiviral vector genomes: intracellular visualization at ultrastructural resolution levels.Use of the PSA enhancer core element to modulate the expression of prostate- and non-prostate-specific basal promoters in a lentiviral vector context.Assessment of the role of the central DNA flap in human immunodeficiency virus type 1 replication by using a single-cycle replication system.Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.Compensatory role of human immunodeficiency virus central polypurine tract sequence in kinetically disrupted reverse transcription.Differentiation of Human Mesenchymal Stem Cells into Insulin Producing Cells by Using A Lentiviral Vector Carrying PDX1.Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction.Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors.Hepatic lentiviral gene transfer prevents the long-term onset of hepatic tumours of glycogen storage disease type 1a in mice.Priming of hepatocytes enhances in vivo liver transduction with lentiviral vectors in adult mice.Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis.Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells.Newborn liver gene transfer by an HIV-2-based lentiviral vector.Transplantation of murine bone marrow stromal cells under the kidney capsule to secrete coagulation factor VIII.Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector.TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability.The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes
P2860
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P2860
Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Modified HIV-1 based lentivira ...... pression in vitro and in vivo.
@en
type
label
Modified HIV-1 based lentivira ...... pression in vitro and in vivo.
@en
prefLabel
Modified HIV-1 based lentivira ...... pression in vitro and in vivo.
@en
P356
P1433
P1476
Modified HIV-1 based lentivira ...... pression in vitro and in vivo.
@en
P304
P356
10.1006/MTHE.2001.0450
P577
2001-09-01T00:00:00Z