Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.
about
Erythroid-specific human factor IX delivery from in vivo selected hematopoietic stem cells following nonmyeloablative conditioning in hemophilia B miceGene therapy for hemophiliaTransient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII.In vivo efficacy of platelet-delivered, high specific activity factor VIII variantsDirected engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.Advancements in gene transfer-based therapy for hemophilia A.In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infectionCorrection of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation.Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens.Genetic engineering for haemophilia A.Syngeneic transplantation of hematopoietic stem cells that are genetically modified to express factor VIII in platelets restores hemostasis to hemophilia A mice with preexisting FVIII immunitySupplying clotting factors from hematopoietic stem cell-derived erythroid and megakaryocytic lineage cells.Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies.A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.Stem cell-derived erythroid cells mediate long-term systemic protein delivery.Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells
P2860
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P2860
Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Recombinant factor VIII expres ...... owing lentiviral transduction.
@en
type
label
Recombinant factor VIII expres ...... owing lentiviral transduction.
@en
prefLabel
Recombinant factor VIII expres ...... owing lentiviral transduction.
@en
P2093
P2860
P356
P1433
P1476
Recombinant factor VIII expres ...... lowing lentiviral transduction
@en
P2093
von Depka M
P2860
P2888
P304
P356
10.1038/SJ.GT.3302093
P50
P577
2003-10-01T00:00:00Z
P5875
P6179
1049209099