Evidence for the transforming activity of a truncated Int6 gene, in vitro.
about
Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulationThe let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiationTargeting translation initiation in breast cancerThe INT6 cancer gene and MEK signaling pathways converge during zebrafish developmentThe Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motifAssociation of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasomeTranslation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.Genetic alterations of chromosome 8 genes in oral cancer.Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domainCommon integration sites for MMTV in viral induced mouse mammary tumors.Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.Hypoxia-inducible factor as an angiogenic master switchInteraction with the mammary microenvironment redirects spermatogenic cell fate in vivoOn the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation.INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cellsINT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodaiHypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors.Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments.Activation of AP-1-dependent transcription by a truncated translation initiation factor.Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling.Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h.The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).An oncogenic role of eIF3e/INT6 in human breast cancer.Techniques for the Reprogramming of Exogenous Stem/Progenitor Cell Populations Towards a Mammary Epithelial Cell Fate.eIF3 Regulation of Protein Synthesis, Tumorigenesis, and Therapeutic Response.EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma.eIF3: a factor for human health and disease.
P2860
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P2860
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
@en
type
label
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
@en
prefLabel
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
@en
P2093
P2860
P356
P1433
P1476
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204624
P407
P577
2001-08-01T00:00:00Z
P5875
P6179
1045497475